{"id":"W1989367572","doi":"10.1371/journal.pone.0054982","title":"Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrPC): Single Molecule Discrimination and PrPC Kinetics","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nanopore and Nanochannel Transport Studies","field":"Engineering","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; National Institute for Nanotechnology; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Oxford Nanopore Technologies","keywords":"Mutant; Fatal familial insomnia; Nanopore; Wild type; Kinetics; Prion protein; Mutation; Biology; Gene isoform; Point mutation; Mutant protein; Protein structure; Biophysics; Chemistry; Cell biology; Genetics; Biochemistry; Materials science; Nanotechnology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376472,0.0001036619,0.000167381,0.0001757662,0.0001125928,0.0001629653,0.0001856676,0.0003071238,0.0003455286],"category_scores_gemma":[0.0002262669,0.00006828129,0.0001082713,0.0001071941,0.0001795242,0.0002661186,0.0001240369,0.0002671579,0.00009383194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882419,"about_ca_system_score_gemma":0.00007630035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005699304,"about_ca_topic_score_gemma":0.0006284805,"domain_scores_codex":[0.9999183,0.000005845593,0.00000510685,0.00002473081,0.00003185803,0.00001409386],"domain_scores_gemma":[0.999821,0.00007597869,0.00003365061,0.00001183271,0.00003306067,0.00002460558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002279146,0.00001111665,0.0003519788,0.00001674712,0.000003134183,0.00002859789,0.00001649002,0.0001649055,0.9987702,0.0000534907,0.00001009222,0.0005504437],"study_design_scores_gemma":[0.000004327463,0.0001934907,0.01371037,0.000004812988,0.00001108477,0.0003262904,0.0000639409,0.01704462,0.9681188,0.00009134818,0.0004173345,0.00001364795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911342,0.0002373814,0.007996909,0.00002752266,0.000007883067,0.0000134766,0.0001806698,0.00006900259,0.0003329898],"genre_scores_gemma":[0.9911991,0.0002085043,0.007745954,0.00003192008,0.000003941053,0.00002307975,0.0001772441,0.00001182622,0.0005984291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005699304,"threshold_uncertainty_score":0.00136584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02102488820675843,"score_gpt":0.1850671994682282,"score_spread":0.1640423112614698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}