{"id":"W1989421786","doi":"10.1038/ng1068","title":"DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells","year":2002,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":611,"is_retracted":false,"has_abstract":false,"ca_institutions":"Parks Canada","funders":"","keywords":"DNMT1; DNA methylation; Biology; Methylation; DNA methyltransferase; Gene silencing; Methyltransferase; Cancer research; CpG site; Tumor suppressor gene; Molecular biology; Cancer epigenetics; Cancer; Carcinogenesis; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335038,0.0001986537,0.0001716002,0.000117025,0.00008865441,0.00003472431,0.0001428465,0.0004791315,0.00006565636],"category_scores_gemma":[0.00003382664,0.0002089175,0.00004830635,0.0002009189,0.00003336434,0.000003692914,0.0001009947,0.0002241582,0.00000511882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004251198,"about_ca_system_score_gemma":0.00001997747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004848217,"about_ca_topic_score_gemma":0.0002304535,"domain_scores_codex":[0.9986517,0.00006553876,0.000288434,0.000491743,0.000197322,0.0003052414],"domain_scores_gemma":[0.9993487,0.00001202272,0.00008395028,0.0003333103,0.00009658421,0.000125408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001133638,0.0000282041,0.003294643,0.0000142478,0.00001614913,0.000002585003,0.0003062384,0.001136404,0.9866717,0.00001949978,0.0005415825,0.007957452],"study_design_scores_gemma":[0.0004305051,0.000172779,0.009112878,0.00001861671,0.00001882105,0.000001079948,0.00003515953,0.001017169,0.9800721,0.0004096107,0.008445429,0.0002658097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768552,0.02042037,0.001482493,0.0003484183,0.0002379462,0.0002782595,0.00003511191,0.000008906597,0.0003332492],"genre_scores_gemma":[0.9919408,0.003211123,0.003336665,0.0007183033,0.0003150625,0.0000329566,0.00003460911,0.00003475269,0.0003757599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01720924,"threshold_uncertainty_score":0.8519409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544785194000415,"score_gpt":0.2888930901438567,"score_spread":0.2734452382038526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}