{"id":"W1989421786","doi":"10.1038/ng1068","title":"DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells","year":2002,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":611,"is_retracted":false,"has_abstract":false,"ca_institutions":"Parks Canada","funders":"","keywords":"DNMT1; DNA methylation; Biology; Methylation; DNA methyltransferase; Gene silencing; Methyltransferase; Cancer research; CpG site; Tumor suppressor gene; Molecular biology; Cancer epigenetics; Cancer; Carcinogenesis; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559324,0.0001566961,0.0002901418,0.0002228515,0.0002354979,0.0004571484,0.0002437264,0.0002580647,0.001219966],"category_scores_gemma":[0.0004194379,0.0002946317,0.0001641723,0.0002285276,0.0002208781,0.0002090084,0.0002553363,0.0004880516,0.0005792931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005764664,"about_ca_system_score_gemma":0.0003434627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002657277,"about_ca_topic_score_gemma":0.002907963,"domain_scores_codex":[0.9999079,0.00001210229,0.000008103319,0.00002138576,0.00002967012,0.00002088261],"domain_scores_gemma":[0.9998459,0.00002925967,0.00003633398,0.00003517351,0.00002195023,0.00003139997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056397,0.000008213063,0.001242806,0.00005967269,0.00001683327,0.00012271,0.00002931734,0.000196929,0.9936639,0.0004802302,0.0001889565,0.003784756],"study_design_scores_gemma":[0.0000250993,0.00008365403,0.01714267,0.000007065539,0.00003944616,0.0009140567,0.00003955696,0.001544456,0.9711205,0.0003933968,0.008681986,0.000008035678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818392,0.007277218,0.005608723,0.0005765533,0.00006682418,0.00002335965,0.0011548,0.0003683524,0.00308494],"genre_scores_gemma":[0.9949067,0.0009955202,0.001356413,0.00003798104,0.000008983102,0.00001054629,0.0005996441,0.00002905954,0.002055033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002657277,"threshold_uncertainty_score":0.005283654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544785194000415,"score_gpt":0.2888930901438567,"score_spread":0.2734452382038526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}