{"id":"W1989424614","doi":"10.1016/j.exphem.2004.02.001","title":"Expression of an anti-sickling β-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells","year":2004,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Center for Research Resources; National Institutes of Health; National Heart, Lung, and Blood Institute; Fred Hutchinson Cancer Research Center","keywords":"Haematopoiesis; Biology; Molecular biology; Globin; Genetic enhancement; Locus control region; CD34; Stem cell; Viral vector; Green fluorescent protein; Progenitor cell; Myeloid; Virology; Gene; Gene expression; Cell biology; Recombinant DNA; Enhancer; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000621982,0.0002741594,0.0006319065,0.0001335218,0.00009383038,0.000009557246,0.0001022225,0.0002219322,0.000106104],"category_scores_gemma":[0.000007107212,0.000253954,0.000097909,0.0001227456,0.0003116805,0.0001614422,0.00007053053,0.000252383,0.000007686101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007447774,"about_ca_system_score_gemma":0.00009611892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002223595,"about_ca_topic_score_gemma":0.00001414909,"domain_scores_codex":[0.9983455,0.0000814592,0.0005167937,0.0004860824,0.0001950623,0.0003750919],"domain_scores_gemma":[0.9992355,0.00003000721,0.0001367696,0.0002777164,0.00002669264,0.0002933284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004646433,0.00156062,0.003126556,0.000157778,0.00001535405,0.0004263404,0.006291014,0.00007533496,0.9873799,0.0004718414,0.000005406508,0.00002520359],"study_design_scores_gemma":[0.00700887,0.0006487278,0.006053321,0.0004768911,0.00004102646,0.00006194796,0.0061745,0.00005919064,0.9790766,0.0001595197,0.000002635845,0.0002367416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950008,0.003703908,0.00009058341,0.00009948465,0.00009599327,0.0005355994,0.00001653074,0.00005218982,0.0004048902],"genre_scores_gemma":[0.9984133,0.00004693004,0.001238203,0.0001296459,0.00002067819,0.00002346683,0.00007685656,0.00003921154,0.00001171315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00830328,"threshold_uncertainty_score":0.9999913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006990434743698057,"score_gpt":0.2522052845215834,"score_spread":0.2452148497778853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}