{"id":"W1989468344","doi":"10.1016/j.chembiol.2008.05.018","title":"Identification of Polyoxometalates as Nanomolar Noncompetitive Inhibitors of Protein Kinase CK2","year":2008,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Polyoxometalates: Synthesis and Applications","field":"Materials Science","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut National Du Cancer; Institute of Cancer Research; Université Pierre et Marie Curie; Institut Universitaire de France; Ligue Contre le Cancer","keywords":"Identification (biology); Biology; Kinase; Biochemistry; Protein kinase A; Computational biology; Pharmacology; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753109,0.0004655986,0.0003233853,0.0002811604,0.0001876685,0.0004739114,0.0005033734,0.0003889511,0.001318037],"category_scores_gemma":[0.0002065162,0.0002782911,0.0001976106,0.0001463478,0.0002401412,0.00025914,0.0002728946,0.0006242198,0.000329641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004642084,"about_ca_system_score_gemma":0.0002310346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002176834,"about_ca_topic_score_gemma":0.0007558096,"domain_scores_codex":[0.9998963,0.00001521502,0.000006994317,0.000019669,0.00003254622,0.0000291856],"domain_scores_gemma":[0.9999337,0.00001840439,0.00001511691,0.000008092053,0.0000105325,0.00001415548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000642462,0.00009903456,0.0001117343,0.0001146475,0.00001344589,0.00007141326,0.00002845148,0.0003049281,0.9903327,0.0008061023,0.0003041092,0.007171079],"study_design_scores_gemma":[0.00009707401,0.0004740074,0.0003284413,0.00000507398,0.00001398288,0.0001297322,0.000009027241,0.0009192212,0.9941542,0.0001205511,0.003741903,0.000006918403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642251,0.006363724,0.01940672,0.000446915,0.0002066847,0.0003132902,0.0004150595,0.0003504846,0.008272081],"genre_scores_gemma":[0.9863487,0.001996867,0.006146015,0.0001282937,0.00002821334,0.0001287753,0.0003612881,0.00003509416,0.004826568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318037,"threshold_uncertainty_score":0.004409254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009595719903073294,"score_gpt":0.2394559103630315,"score_spread":0.2298601904599583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}