{"id":"W1989470650","doi":"10.1038/sj.bjp.0704644","title":"Rolipram inhibits leukocyte‐endothelial cell interactions <i>in vivo</i> through P‐ and E‐selectin downregulation","year":2002,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Rolipram; Intravital microscopy; Downregulation and upregulation; Chemistry; Intercellular Adhesion Molecule-1; Phosphodiesterase inhibitor; Internal medicine; In vivo; Cell adhesion; Endocrinology; Cell adhesion molecule; Endothelial stem cell; Inflammation; Pharmacology; Phosphodiesterase; Biology; Immunology; Medicine; Cell; Microcirculation; In vitro; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404454,0.00009522292,0.000150151,0.00006647044,0.00008006006,0.00002975608,0.00006345203,0.00007779299,0.0003856711],"category_scores_gemma":[0.0000240802,0.0001099478,0.00006473934,0.00009078794,0.00006134217,0.00003180961,0.00003067016,0.0001955816,0.000003875148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003098611,"about_ca_system_score_gemma":0.00002554155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003233455,"about_ca_topic_score_gemma":0.0001209871,"domain_scores_codex":[0.999136,0.0001201615,0.0003409555,0.0001540589,0.00008626527,0.0001625807],"domain_scores_gemma":[0.9995624,0.00002270328,0.0002164116,0.00003490187,0.0001102188,0.00005331917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001484688,0.0001648337,0.0003062302,0.00000931563,0.00002739188,0.00004087935,0.00008818968,0.0003918967,0.9628787,0.000003956295,0.03153833,0.004401827],"study_design_scores_gemma":[0.002901983,0.0002317784,0.001002559,0.00002729138,0.00003485816,0.003143195,0.00003803752,0.0005732629,0.8740129,0.00004202726,0.1178632,0.00012883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937347,0.003201528,0.0004534943,0.0003446609,0.0008271262,0.0001060707,0.00001086271,0.000005391847,0.001316233],"genre_scores_gemma":[0.9939185,0.00313227,0.000333254,0.0006276694,0.0006344892,0.000004730678,0.000006182533,0.00001288664,0.001329973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08886573,"threshold_uncertainty_score":0.4483542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256631981202783,"score_gpt":0.2618188671559971,"score_spread":0.2492525473439693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}