{"id":"W1989488426","doi":"10.1016/j.immuni.2010.05.011","title":"Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction","year":2010,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Austrian Science Fund; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK; Wellcome Trust","keywords":"T-cell receptor; Biology; Cell biology; Signal transduction; CD28; T cell; Phosphorylation; ZAP70; Receptor; Kinase; Jurkat cells; CD3; Antigen; Immune system; Immunology; Biochemistry; CD8","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457744,0.0002526748,0.0001766675,0.0002181118,0.0001806577,0.000506826,0.000182745,0.0002246034,0.0005553778],"category_scores_gemma":[0.0001247329,0.0001447003,0.0001598099,0.0002111448,0.0003457415,0.0002532153,0.0002250197,0.0006973924,0.0004074216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004487541,"about_ca_system_score_gemma":0.0002047084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003313785,"about_ca_topic_score_gemma":0.0005445316,"domain_scores_codex":[0.9998145,0.00003049575,0.00002060123,0.00004229638,0.00004416352,0.00004795711],"domain_scores_gemma":[0.9999079,0.00001655207,0.00002344174,0.000019914,0.000007560576,0.00002466632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003861704,0.00001220134,0.00007049007,0.00001165454,9.589162e-7,0.00002307517,0.000006975755,0.00002433243,0.9990667,0.0001369521,0.00001897493,0.0005891733],"study_design_scores_gemma":[0.000009735606,0.00008401566,0.0009451145,0.000002734576,0.000007012642,0.0002018072,0.00001026427,0.0006187915,0.9964339,0.0001041336,0.001579201,0.000003346353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913135,0.001712637,0.004843286,0.00009765338,0.00003609621,0.0000248856,0.0002529752,0.0001281966,0.001590897],"genre_scores_gemma":[0.9942227,0.0008445804,0.003076639,0.00002986444,0.00001954474,0.00002020728,0.0003233346,0.00002797741,0.001435036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005553778,"threshold_uncertainty_score":0.003255904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107241528387616,"score_gpt":0.2347093097442794,"score_spread":0.2239851569055178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}