{"id":"W1989502045","doi":"10.4137/cmt.s3783","title":"Lapatinib, a Dual-Targeted Small Molecule Inhibitor of EGFR and HER2, in HER2-Amplified Breast Cancer: From Bench to Bedside","year":2011,"lang":"en","type":"article","venue":"Clinical Medicine Insights Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Lapatinib; Trastuzumab; Breast cancer; Cancer research; Medicine; Tyrosine kinase; Tyrosine-kinase inhibitor; Epidermal growth factor receptor; Metastatic breast cancer; Cancer; Targeted therapy; Pertuzumab; Letrozole; Oncology; Internal medicine; Receptor; Tamoxifen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005209575,0.0002636867,0.0003507814,0.0002813956,0.0001240751,0.0004870361,0.0002903806,0.0006442088,0.001050717],"category_scores_gemma":[0.0002777477,0.00008802707,0.0001713923,0.0002478746,0.0002070327,0.0006485138,0.0002727107,0.0008231355,0.000418749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003409908,"about_ca_system_score_gemma":0.0002516528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000143465,"about_ca_topic_score_gemma":0.0006338209,"domain_scores_codex":[0.9998848,0.00004046037,0.000009618837,0.00001247986,0.00003361975,0.00001888597],"domain_scores_gemma":[0.9999368,0.0000232259,0.00001025708,0.000001958627,0.00001049266,0.00001726779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001055385,0.0006003969,0.001280529,0.001260327,0.00004207518,0.001834817,0.0001404662,0.0007552371,0.06811406,0.005163334,0.02129564,0.8984578],"study_design_scores_gemma":[0.002317633,0.01141565,0.01083467,0.0005829138,0.0003271528,0.03198189,0.0003027174,0.004540395,0.1261774,0.006713665,0.80471,0.00009573004],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05774067,0.9065737,0.006178422,0.01139361,0.0009187723,0.00008223692,0.00007561404,0.0001647776,0.01687221],"genre_scores_gemma":[0.3252656,0.6409555,0.00881838,0.005087157,0.002385939,0.000102232,0.0002338696,0.00002729193,0.01712411],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001050717,"threshold_uncertainty_score":0.003515005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1881386438902378,"score_gpt":0.4205964844946525,"score_spread":0.2324578406044146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}