{"id":"W1989503397","doi":"10.1016/j.leukres.2005.05.014","title":"Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: Lamin B1 is a novel target of VAA-I","year":2005,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Apoptosis; Biology; Caspase; Cytoskeleton; Molecular biology; Cell culture; Cell biology; Programmed cell death; Lamin; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151527,0.000325446,0.0001727339,0.0002491862,0.0002324482,0.0002887592,0.0002159105,0.0003033844,0.001073811],"category_scores_gemma":[0.0001074345,0.0001294054,0.0002703479,0.0002336495,0.0001721758,0.0002074439,0.0001754557,0.0004934323,0.0003507315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004135557,"about_ca_system_score_gemma":0.0001564975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006957312,"about_ca_topic_score_gemma":0.0006659961,"domain_scores_codex":[0.9998864,0.0000232358,0.00001165196,0.00001754804,0.00002063933,0.00004046684],"domain_scores_gemma":[0.9999298,0.00001401727,0.00001928567,0.00001317326,0.000006285554,0.00001734329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003307207,0.00003509115,0.0003557416,0.00002307316,0.000008856658,0.00008964386,0.00001370846,0.00006166669,0.9981204,0.0001590881,0.00003116375,0.0007708654],"study_design_scores_gemma":[0.00003432691,0.0004061144,0.007183868,0.00000361357,0.00001833039,0.0004552143,0.00002983531,0.0007952609,0.9896825,0.00006582327,0.00132279,0.000002323567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959145,0.001306816,0.001471787,0.00007868434,0.00001481879,0.00001549814,0.0001932706,0.00005144693,0.0009531472],"genre_scores_gemma":[0.9978065,0.0003900624,0.0004776812,0.00001795883,0.000004499917,0.000013699,0.0003193026,0.000006036135,0.000964259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073811,"threshold_uncertainty_score":0.003592253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948602253936718,"score_gpt":0.2987208400689949,"score_spread":0.2692348175296277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}