{"id":"W1989503397","doi":"10.1016/j.leukres.2005.05.014","title":"Viscum album agglutinin-I (VAA-I) induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases: Lamin B1 is a novel target of VAA-I","year":2005,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Apoptosis; Biology; Caspase; Cytoskeleton; Molecular biology; Cell culture; Cell biology; Programmed cell death; Lamin; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001451564,0.0003140595,0.0006299154,0.0006626046,0.0002910577,0.00003544853,0.0004109033,0.0005875368,0.0003230977],"category_scores_gemma":[0.0001332592,0.0002928153,0.00009264217,0.0004734135,0.0007498805,0.0002991294,0.0004219218,0.001064219,0.00003419581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004773151,"about_ca_system_score_gemma":0.0004919292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004631777,"about_ca_topic_score_gemma":0.0004000292,"domain_scores_codex":[0.997136,0.000405254,0.0007740814,0.0006346073,0.0002465736,0.0008034598],"domain_scores_gemma":[0.9987002,0.0002677269,0.000265161,0.0004937446,0.0002059686,0.00006720728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001841103,0.0002234021,0.0004254467,0.0001688511,0.00009666141,0.000002187608,0.001786739,0.00001407173,0.9906316,0.0008963395,0.0003701382,0.00520049],"study_design_scores_gemma":[0.003206395,0.0008104562,0.003944213,0.0001704312,0.00002074954,0.00001923165,0.0009439428,0.0001935452,0.9882514,0.0002885173,0.001873023,0.000278125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966002,0.001225507,0.0003999328,0.0001925172,0.00008239486,0.0009410983,0.0001352936,0.00002421337,0.0003988373],"genre_scores_gemma":[0.9951536,0.0002491947,0.002135498,0.00005011155,0.00004147193,0.0001022921,0.0000814424,0.00004129299,0.002145085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004922365,"threshold_uncertainty_score":0.9999524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948602253936718,"score_gpt":0.2987208400689949,"score_spread":0.2692348175296277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}