{"id":"W1989507218","doi":"10.1006/mcne.2000.0909","title":"Mutant Huntingtin Enhances Excitotoxic Cell Death","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":195,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Huntingtin; Excitotoxicity; Biology; NMDA receptor; Neurodegeneration; Programmed cell death; Cell biology; Glutamate receptor; Apoptosis; Polyglutamine tract; Huntington's disease; Mutant; Molecular biology; Receptor; Genetics; Gene; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615053,0.0004713637,0.0007321726,0.0005749325,0.0002758932,0.0005276884,0.0004411686,0.0007391718,0.002921109],"category_scores_gemma":[0.0004320306,0.0003412226,0.0004434938,0.0003865284,0.0004017655,0.0005942131,0.0004596228,0.001006756,0.0004535429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004840934,"about_ca_system_score_gemma":0.0003628281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001555691,"about_ca_topic_score_gemma":0.00234058,"domain_scores_codex":[0.9996715,0.000074098,0.0000486292,0.00004105668,0.00006317125,0.0001015962],"domain_scores_gemma":[0.9994406,0.0001817661,0.00006789887,0.0001022669,0.00004339407,0.0001640996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009075103,0.0001403519,0.0002281285,0.00005296178,0.00003837308,0.0002877811,0.00003240822,0.000121661,0.9967975,0.0002961378,0.00008023436,0.001016991],"study_design_scores_gemma":[0.00007380567,0.001090065,0.00485211,0.00001132936,0.00005972088,0.0008782826,0.00005784593,0.0006678491,0.991281,0.0001606711,0.0008591446,0.000008281856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958048,0.0009151486,0.0008694293,0.0000750093,0.00005093703,0.00002339525,0.0001727894,0.00006842166,0.002020017],"genre_scores_gemma":[0.9961487,0.0005580215,0.0005873785,0.00005159795,0.00001953703,0.00001866462,0.0002045768,0.00003379645,0.002377755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002921109,"threshold_uncertainty_score":0.009772062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925645460934016,"score_gpt":0.2398021093512085,"score_spread":0.2205456547418683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}