{"id":"W1989507218","doi":"10.1006/mcne.2000.0909","title":"Mutant Huntingtin Enhances Excitotoxic Cell Death","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":195,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Huntingtin; Excitotoxicity; Biology; NMDA receptor; Neurodegeneration; Programmed cell death; Cell biology; Glutamate receptor; Apoptosis; Polyglutamine tract; Huntington's disease; Mutant; Molecular biology; Receptor; Genetics; Gene; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001418658,0.0003114731,0.0002059275,0.0001294656,0.0004262194,0.0002521037,0.0005597898,0.00004974337,0.00004510578],"category_scores_gemma":[0.0003746919,0.0002949973,0.00009877313,0.0006260393,0.0003772338,0.0001872336,0.0002368616,0.000179956,0.00004645358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001167012,"about_ca_system_score_gemma":0.00005935806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007388424,"about_ca_topic_score_gemma":8.358949e-7,"domain_scores_codex":[0.9969926,0.0002596757,0.0002747269,0.001221707,0.0006091972,0.0006420568],"domain_scores_gemma":[0.9989837,0.0000710778,0.0001156225,0.0004874651,0.00003536127,0.0003067314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009814619,0.0001147003,0.0007644229,0.00001137098,2.892632e-7,0.0005590619,0.00004343671,0.0001213201,0.9973816,0.0005473923,0.000009787947,0.000436809],"study_design_scores_gemma":[0.0002542543,0.0001495075,0.0008403452,0.000008255107,0.000011636,0.0000857515,0.00001830765,0.001443357,0.9947087,0.0003986514,0.001762117,0.0003190859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847133,0.00020701,0.01066736,0.000154042,0.0003749284,0.0003026018,0.000007055949,0.0001069328,0.003466723],"genre_scores_gemma":[0.9960586,0.0001687748,0.0001711814,0.00295534,0.00004141791,0.00002716318,9.493526e-7,0.00003568167,0.0005409375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01134521,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925645460934016,"score_gpt":0.2398021093512085,"score_spread":0.2205456547418683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}