{"id":"W1989514551","doi":"10.1016/j.joca.2013.02.031","title":"Creating conditional knockout mice for OA research","year":2013,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"","keywords":"Conditional gene knockout; Gene knockout; Cre recombinase; Knockout mouse; Cartilage; Gene targeting; Chondrogenesis; Biology; Cre-Lox recombination; Gene knockin; Gene; Transgene; Cell biology; Computational biology; Genetics; Genetically modified mouse; Anatomy; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003620665,0.002092927,0.001700826,0.003997519,0.001216494,0.001846178,0.003093092,0.003127983,0.01322976],"category_scores_gemma":[0.001410587,0.002269104,0.002228416,0.001190907,0.001985827,0.002075952,0.001745053,0.004983854,0.004951715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006804088,"about_ca_system_score_gemma":0.001116023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007629981,"about_ca_topic_score_gemma":0.002163568,"domain_scores_codex":[0.9971477,0.0004552841,0.0005668838,0.0005178284,0.0008428479,0.0004693164],"domain_scores_gemma":[0.9969705,0.0006775141,0.0009182187,0.0005167926,0.0002868397,0.0006300755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005025226,0.0002461046,0.0004091327,0.0002728313,0.00008444612,0.0004087777,0.0001287066,0.0002623966,0.9852128,0.00474458,0.001336806,0.006390836],"study_design_scores_gemma":[0.0008331546,0.00068001,0.00275214,0.0002868463,0.0006553144,0.003139735,0.0002377067,0.002253518,0.9285649,0.00158926,0.05889928,0.0001080953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4712937,0.01009074,0.4584526,0.004037548,0.002850771,0.00403689,0.02039308,0.01073732,0.01810737],"genre_scores_gemma":[0.5807073,0.01381881,0.3269385,0.002184565,0.0005412298,0.005511348,0.0146396,0.006742343,0.04891657],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01322976,"threshold_uncertainty_score":0.04425794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02879545853967057,"score_gpt":0.3047189435374403,"score_spread":0.2759234849977697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}