{"id":"W1989518660","doi":"10.1042/bj20150049","title":"Retrocyclins neutralize bacterial toxins by potentiating their unfolding","year":2015,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service","keywords":"Toxin; Chemistry; Proteolysis; Peptide; Anthrax toxin; Biochemistry; Biology; Bacteria; Defensin; Biophysics; Microbiology; Fusion protein; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173933,0.0003904099,0.0002487217,0.0002116279,0.0000737075,0.0001837918,0.0001374349,0.0002430914,0.0009601616],"category_scores_gemma":[0.0001915838,0.0000778766,0.0002087312,0.0001057673,0.0002239399,0.0002019037,0.0001705116,0.0005244104,0.000186873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581957,"about_ca_system_score_gemma":0.0001533855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002160336,"about_ca_topic_score_gemma":0.0002775307,"domain_scores_codex":[0.9998205,0.00003962238,0.00001129471,0.000036619,0.00005708007,0.00003478964],"domain_scores_gemma":[0.9998318,0.0000411395,0.0000599687,0.00001642721,0.00002563904,0.0000250116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007567838,0.0000199487,0.0001133038,0.00002734824,0.000003250691,0.00001590181,0.000009723223,0.00002434976,0.9979207,0.00004038451,0.00002045265,0.001729087],"study_design_scores_gemma":[0.000008854984,0.000492778,0.001593853,0.000004136189,0.000005559071,0.0001158053,0.000009365286,0.0002972633,0.9964787,0.00002960099,0.0009611899,0.000002740406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991221,0.003708886,0.003805308,0.00009886322,0.000042209,0.00004442121,0.00009321093,0.00008765882,0.0008985247],"genre_scores_gemma":[0.9939797,0.001452046,0.002782104,0.0001082806,0.0000250739,0.00002772063,0.0001453589,0.00001523282,0.001464446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009601616,"threshold_uncertainty_score":0.003212094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104794241240217,"score_gpt":0.2327034300233211,"score_spread":0.2116554876109189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}