{"id":"W1989531230","doi":"10.1371/journal.ppat.1002391","title":"Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Wellcome Trust; Fondation pour la Recherche Médicale; M.J. Murdock Charitable Trust; National Institutes of Health; U.S. Department of Commerce","keywords":"Scrapie; Genetically modified mouse; Biology; Transgene; Neurodegeneration; Fatal familial insomnia; Endogeny; PRNP; Cell biology; Bovine spongiform encephalopathy; Virology; Disease; Prion protein; Gene; Genetics; Pathology; Medicine; Biochemistry; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009636395,0.0002246583,0.000215672,0.0002035465,0.0001267353,0.0002817989,0.0001090683,0.0002738872,0.0006723538],"category_scores_gemma":[0.0002008294,0.0001271713,0.0001477753,0.00009482561,0.0002667974,0.0002133852,0.0002193462,0.0004620807,0.0002656309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462368,"about_ca_system_score_gemma":0.00008914348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002482706,"about_ca_topic_score_gemma":0.0004584396,"domain_scores_codex":[0.999884,0.00001462978,0.00001491821,0.00003100805,0.00003023325,0.0000252123],"domain_scores_gemma":[0.9997551,0.00004684488,0.00007721838,0.00002394136,0.00002864947,0.00006832927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006195297,0.0000116631,0.0003309815,0.00001034281,0.000001736043,0.00004815639,0.000008530717,0.00000403479,0.9992189,0.00001567129,0.00000486864,0.0002831437],"study_design_scores_gemma":[0.000009039991,0.0006945183,0.06150769,0.00001012412,0.00001926361,0.00086601,0.00009351217,0.0004286114,0.9353788,0.00009738204,0.0008854319,0.000009598457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979134,0.0005802752,0.0007257377,0.00002126679,0.000007906119,0.000009781113,0.0001347839,0.00003308005,0.0005736874],"genre_scores_gemma":[0.9968655,0.0003168119,0.001018961,0.00003589902,0.000007045052,0.00001363673,0.0004860611,0.00001344322,0.00124268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006723538,"threshold_uncertainty_score":0.002249181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0574603494053073,"score_gpt":0.3298924207919695,"score_spread":0.2724320713866621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}