{"id":"W1989531230","doi":"10.1371/journal.ppat.1002391","title":"Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation","year":2011,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Wellcome Trust; Fondation pour la Recherche Médicale; M.J. Murdock Charitable Trust; National Institutes of Health; U.S. Department of Commerce","keywords":"Scrapie; Genetically modified mouse; Biology; Transgene; Neurodegeneration; Fatal familial insomnia; Endogeny; PRNP; Cell biology; Bovine spongiform encephalopathy; Virology; Disease; Prion protein; Gene; Genetics; Pathology; Medicine; Biochemistry; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002797726,0.0001047146,0.000138869,0.00008862277,0.00003701841,0.00000470997,0.00009074509,0.0001743745,0.0001094694],"category_scores_gemma":[0.0002668249,0.0001056455,0.0001100414,0.0001826428,0.00002669895,0.000009714132,0.00006516936,0.00007380714,0.00001448045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000168254,"about_ca_system_score_gemma":0.00005639511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003631345,"about_ca_topic_score_gemma":0.00008595111,"domain_scores_codex":[0.998896,0.0001365328,0.0004317894,0.0002788771,0.0001125544,0.0001442631],"domain_scores_gemma":[0.9994258,0.0000158987,0.0001448045,0.0002428848,0.00007820871,0.00009242586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002331158,0.0006124572,0.3008156,0.00003213876,0.00006983603,0.00000139223,0.0005908892,0.0008430064,0.6829655,0.00009919623,0.00005332102,0.01368351],"study_design_scores_gemma":[0.0005767833,0.0005145474,0.9158027,0.00006922239,0.00004603026,0.000001964204,0.00004039664,0.001461596,0.08039308,0.0004452668,0.0004762215,0.0001722374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982083,0.0002952894,0.0006362979,0.00003240789,0.0000738162,0.000524218,0.00002073177,0.00001601794,0.0001929267],"genre_scores_gemma":[0.9986302,0.0002140998,0.0008867267,0.00004219606,0.00003968317,0.00004540612,0.00007695598,0.00001399145,0.00005072864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6149871,"threshold_uncertainty_score":0.43081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0574603494053073,"score_gpt":0.3298924207919695,"score_spread":0.2724320713866621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}