{"id":"W1989545813","doi":"10.1097/01.cad.0000224442.78211.27","title":"Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects","year":2006,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Manitoba","funders":"National Cancer Institute","keywords":"Topoisomerase; Chinese hamster ovary cell; Cell cycle; Diazo; Cell growth; Biochemistry; Biology; DNA synthesis; DNA gyrase; Cell; Mechanism of action; Chemistry; DNA; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008172083,0.0002983226,0.0002126857,0.0002542793,0.0001102954,0.0001750994,0.0001403196,0.0003368441,0.0006180324],"category_scores_gemma":[0.00007679709,0.00007623751,0.0001246221,0.0001811597,0.0001318847,0.0002241016,0.0001278628,0.0001925902,0.0002477863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282533,"about_ca_system_score_gemma":0.000164718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004502617,"about_ca_topic_score_gemma":0.0009763337,"domain_scores_codex":[0.9999359,0.00001553881,0.000007264623,0.00001290276,0.00001644773,0.00001194724],"domain_scores_gemma":[0.9999362,0.000009911704,0.00001592893,0.000006867071,0.00001132039,0.00001975619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001514241,0.00002182647,0.0001657057,0.00009162483,0.000004688684,0.00009739851,0.00001023982,0.0001549974,0.9954258,0.00009706627,0.00002168706,0.003757591],"study_design_scores_gemma":[0.00003474789,0.001097545,0.004315564,0.00001023576,0.00002143591,0.0007740447,0.00002162989,0.0004383236,0.9874617,0.0000800765,0.005733228,0.00001148617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722911,0.02054743,0.003390556,0.000125922,0.0000338789,0.00006966066,0.00029546,0.0001010646,0.003144922],"genre_scores_gemma":[0.9897893,0.004636644,0.003809656,0.00004889794,0.00001228663,0.00003491397,0.0002165895,0.000007160667,0.001444561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006180324,"threshold_uncertainty_score":0.002067566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005652982179236384,"score_gpt":0.2463329000675111,"score_spread":0.2406799178882747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}