{"id":"W1989545813","doi":"10.1097/01.cad.0000224442.78211.27","title":"Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects","year":2006,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Manitoba","funders":"National Cancer Institute","keywords":"Topoisomerase; Chinese hamster ovary cell; Cell cycle; Diazo; Cell growth; Biochemistry; Biology; DNA synthesis; DNA gyrase; Cell; Mechanism of action; Chemistry; DNA; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000127156,0.0003362442,0.0003666401,0.00005806386,0.0001723986,0.0001615933,0.0001408673,0.0001753567,0.00004336497],"category_scores_gemma":[0.000004472259,0.0003176348,0.00008553537,0.00008084698,0.0001356561,0.00003596241,0.0001309386,0.000108713,0.000002942968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002080588,"about_ca_system_score_gemma":0.0001226354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002401128,"about_ca_topic_score_gemma":0.0003273997,"domain_scores_codex":[0.9983867,0.00009662276,0.0002067072,0.0006725556,0.0001929045,0.0004445318],"domain_scores_gemma":[0.9993385,0.00001389882,0.0001271505,0.0002675418,0.00005460939,0.0001983124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003558579,0.0001252794,0.001876587,0.00004627545,0.0001085504,0.000008722285,0.0002165665,0.00001206347,0.9895836,0.0009105444,0.0002403995,0.00651557],"study_design_scores_gemma":[0.003660458,0.0005278359,0.01382,0.00002765589,0.0001754346,0.00001185283,0.0001476182,0.0001724336,0.9654715,0.000868332,0.01464768,0.0004692131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914132,0.005959313,0.001096295,0.0001609216,0.0005256853,0.0004358646,0.0000792827,0.00002418578,0.0003052124],"genre_scores_gemma":[0.9920465,0.004800171,0.000267952,0.0008283869,0.001186583,0.00004362268,0.0001647023,0.00005479444,0.0006072604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02411209,"threshold_uncertainty_score":0.9999276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005652982179236384,"score_gpt":0.2463329000675111,"score_spread":0.2406799178882747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}