{"id":"W1989547406","doi":"10.1067/mlc.2002.120649","title":"Treatment of hemophilia B in mice with nonautologous somatic gene therapeutics","year":2002,"lang":"en","type":"article","venue":"Journal of Laboratory and Clinical Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Factor IX; Antibody; Genetic enhancement; Factor VII; Immune system; Immunology; Thromboplastin; Tissue factor; Molecular biology; Andrology; Medicine; Chemistry; Pharmacology; Internal medicine; Biology; Biochemistry; Coagulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004518521,0.000103582,0.0003762077,0.00005851822,0.00001729758,0.000002454552,0.00009951505,0.000107072,0.00003522174],"category_scores_gemma":[0.00008486304,0.00006139817,0.00004507687,0.0001340053,0.0002887266,0.000003558762,0.000009898302,0.0001222743,8.588574e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001281851,"about_ca_system_score_gemma":0.00008093675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001427937,"about_ca_topic_score_gemma":0.00002489113,"domain_scores_codex":[0.9988023,0.0001923382,0.0005857517,0.0001219642,0.0001741563,0.0001234946],"domain_scores_gemma":[0.9991685,0.0001132181,0.0002654026,0.0001548795,0.0001926015,0.0001054417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007391025,0.001836885,0.1176475,0.00005637917,0.0008065788,0.00031144,0.0004340613,0.00002388254,0.8278601,0.000008871411,0.0001751074,0.04344809],"study_design_scores_gemma":[0.03609357,0.3102043,0.04957478,0.000437076,0.0006575668,0.0005521789,0.0007845492,0.000460181,0.5879886,0.0001940573,0.01254565,0.0005074617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871837,0.01125501,0.00001909626,0.00133393,0.00006868397,0.00008470318,0.000004194537,0.000001127715,0.00004954365],"genre_scores_gemma":[0.9853646,0.0136581,0.0002555487,0.0003637726,0.0002950977,0.000001422833,0.000001437843,0.00001006649,0.00004999242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3083674,"threshold_uncertainty_score":0.2503745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04323416553471185,"score_gpt":0.3633375648888871,"score_spread":0.3201033993541753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}