{"id":"W1989547406","doi":"10.1067/mlc.2002.120649","title":"Treatment of hemophilia B in mice with nonautologous somatic gene therapeutics","year":2002,"lang":"en","type":"article","venue":"Journal of Laboratory and Clinical Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Factor IX; Antibody; Genetic enhancement; Factor VII; Immune system; Immunology; Thromboplastin; Tissue factor; Molecular biology; Andrology; Medicine; Chemistry; Pharmacology; Internal medicine; Biology; Biochemistry; Coagulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003824568,0.0007336477,0.0006588613,0.0009374351,0.0002970313,0.0004501061,0.0005164394,0.001014657,0.002677276],"category_scores_gemma":[0.0002243575,0.0003133985,0.000582423,0.0003405516,0.0006367699,0.000395803,0.0002056932,0.001354177,0.0006081229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966571,"about_ca_system_score_gemma":0.000266374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003685403,"about_ca_topic_score_gemma":0.0003560701,"domain_scores_codex":[0.9996471,0.00009468854,0.00002607869,0.00006081464,0.00008645169,0.00008486895],"domain_scores_gemma":[0.9997407,0.00004490602,0.00009343532,0.00003874022,0.00001256219,0.00006975201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077171,0.0002903565,0.0001428908,0.00006307477,0.00002600741,0.000256391,0.00002785949,0.0001401993,0.9923208,0.0009236113,0.0002705706,0.004460997],"study_design_scores_gemma":[0.0003295787,0.002143405,0.001289861,0.00001611508,0.00005736824,0.001277953,0.00002147617,0.001075622,0.9881896,0.0003014746,0.005282616,0.0000149567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780747,0.004534674,0.009906533,0.0007384957,0.0001808905,0.0002613288,0.001152276,0.0008220758,0.004329089],"genre_scores_gemma":[0.9845048,0.002516262,0.004520225,0.0001586608,0.00006578347,0.0002088382,0.000684018,0.0001234538,0.007218035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002677276,"threshold_uncertainty_score":0.008956313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04323416553471185,"score_gpt":0.3633375648888871,"score_spread":0.3201033993541753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}