{"id":"W1989553730","doi":"10.1523/jneurosci.6384-11.2013","title":"Separate Ca<sup>2+</sup>Sources Are Buffered by Distinct Ca<sup>2+</sup>Handling Systems in<i>Aplysia</i>Neuroendocrine Cells","year":2013,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"SERCA; Endoplasmic reticulum; EGTA; Biophysics; Membrane potential; Depolarization; Aplysia; Calcium; Sodium-calcium exchanger; Plasma membrane Ca2+ ATPase; Chemistry; Biology; Cell biology; ATPase; Intracellular; Biochemistry; Neuroscience; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109187,0.0001753412,0.0002982845,0.0001594118,0.0001857285,0.0006642324,0.0003384165,0.0003485798,0.0003823511],"category_scores_gemma":[0.0001808818,0.0002158842,0.0002898202,0.0001804427,0.0002773125,0.0006462405,0.0004352489,0.0005143412,0.0001952068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004188953,"about_ca_system_score_gemma":0.0001692782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007526568,"about_ca_topic_score_gemma":0.0007413716,"domain_scores_codex":[0.9998845,0.000006912544,0.00001967939,0.00003550526,0.00003398987,0.00001940698],"domain_scores_gemma":[0.9998313,0.00001848225,0.00007064864,0.00002151097,0.00002305301,0.00003500084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005647744,0.000002745285,0.0008127739,0.00002428446,0.000004649375,0.00009536701,0.00003421077,0.0000579172,0.9981863,0.0000641715,0.00001916263,0.0006418831],"study_design_scores_gemma":[0.00003810925,0.0002690461,0.1180572,0.00002572438,0.00007070741,0.001512757,0.0003577082,0.002942586,0.8726557,0.0004712043,0.003566254,0.00003309909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957985,0.0009037586,0.002394963,0.00009049923,0.000007314052,0.000006546197,0.0001880424,0.00006704577,0.0005431792],"genre_scores_gemma":[0.9963658,0.000320699,0.00221684,0.00008579662,0.000006095341,0.00001215113,0.0003144643,0.00002174726,0.0006563911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007526568,"threshold_uncertainty_score":0.00303936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316900420966331,"score_gpt":0.2363787203299688,"score_spread":0.2232097161203055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}