{"id":"W1989560280","doi":"10.1016/j.addr.2004.12.013","title":"The role of cathepsins in osteoporosis and arthritis: Rationale for the design of new therapeutics","year":2005,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":306,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada); University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Cathepsin K; Cathepsin; Proteases; Rheumatoid arthritis; Arthritis; Osteoporosis; Medicine; Cathepsin S; Immune system; Extracellular matrix; Immunology; Biology; Cell biology; Osteoclast; Internal medicine; Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00135382,0.001449362,0.002618,0.001932179,0.0004345475,0.001554975,0.00150964,0.002355655,0.002222668],"category_scores_gemma":[0.0009057265,0.0005272012,0.0007298819,0.002054969,0.001470057,0.002345189,0.0008318623,0.004364056,0.002204476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001485486,"about_ca_system_score_gemma":0.001666833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001243499,"about_ca_topic_score_gemma":0.00205733,"domain_scores_codex":[0.9996476,0.00006850337,0.00004384973,0.00006021006,0.0001442818,0.00003544326],"domain_scores_gemma":[0.9994792,0.000242661,0.00005798222,0.00001906906,0.0001541571,0.00004683749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004148601,0.0002358904,0.0001852071,0.0124907,0.0001409693,0.0005428507,0.00007693993,0.001372335,0.009561814,0.02189896,0.06355237,0.889527],"study_design_scores_gemma":[0.0001241819,0.0001958246,0.0002737227,0.001182054,0.00008475935,0.001143267,0.00004911135,0.0002677093,0.001848409,0.005337499,0.9894652,0.00002825273],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001287643,0.9976633,0.0004596291,0.0006794157,0.0003995414,0.000007275627,0.00001402524,0.00001001189,0.000638077],"genre_scores_gemma":[0.0007684827,0.9971807,0.0006798932,0.0003576083,0.0002692285,0.00001242282,0.00002143207,0.000001308438,0.000708962],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002618,"threshold_uncertainty_score":0.01077795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04093487036622155,"score_gpt":0.3118580138077939,"score_spread":0.2709231434415723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}