{"id":"W1989572440","doi":"10.1016/j.str.2013.02.011","title":"A “New Twist” on RGS Protein Selectivity","year":2013,"lang":"en","type":"letter","venue":"Structure","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Heart and Stroke Foundation; University of Toronto","funders":"","keywords":"RGS2; G protein-coupled receptor; Regulator of G protein signaling; G protein; Cell biology; Scaffold protein; Signal transduction; Biology; GTPase-activating protein; Function (biology); Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00004490498,0.0004020696,0.0002624113,0.00007357541,0.00008439515,0.00006594633,0.0002564865,0.001372484,0.000672291],"category_scores_gemma":[0.0000552889,0.0003492803,0.0001605561,0.00009372889,0.00004262061,0.000002675621,0.0000750883,0.001008139,0.00005058795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003592484,"about_ca_system_score_gemma":0.0002271188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005381446,"about_ca_topic_score_gemma":0.00001247313,"domain_scores_codex":[0.9984148,0.0001006846,0.0001846843,0.0006443766,0.0002906428,0.0003648654],"domain_scores_gemma":[0.9990764,0.000005426855,0.0001628162,0.0005821276,0.000086189,0.00008701862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000197906,0.000003201478,0.00000469377,0.00005934954,0.00004872682,0.00001788039,0.000007094464,0.000009122481,0.2595714,0.00003759972,0.7370537,0.003167425],"study_design_scores_gemma":[0.000239533,0.0001270573,0.00004877945,0.00005498394,0.00001463447,0.00001922663,8.201617e-7,0.000005322252,0.2631011,0.001379224,0.7346658,0.0003435685],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2761005,0.004412068,0.009516235,0.6825548,0.002505254,0.009517672,0.001328534,0.0004594769,0.01360549],"genre_scores_gemma":[0.281137,0.00001691041,0.006729024,0.6079422,0.02963246,0.0001875572,0.005348153,0.0003233473,0.06868336],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07461265,"threshold_uncertainty_score":0.9999239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006504126832962431,"score_gpt":0.2198248547425513,"score_spread":0.2133207279095888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}