{"id":"W1989572440","doi":"10.1016/j.str.2013.02.011","title":"A “New Twist” on RGS Protein Selectivity","year":2013,"lang":"en","type":"letter","venue":"Structure","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Heart and Stroke Foundation; University of Toronto","funders":"","keywords":"RGS2; G protein-coupled receptor; Regulator of G protein signaling; G protein; Cell biology; Scaffold protein; Signal transduction; Biology; GTPase-activating protein; Function (biology); Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001788475,0.0003949465,0.0007989545,0.0002455356,0.001107414,0.002069885,0.001113014,0.00637843,0.003664584],"category_scores_gemma":[0.003306958,0.0002821774,0.0003340572,0.0002258128,0.005738327,0.003247275,0.001001344,0.01109299,0.001363168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001830377,"about_ca_system_score_gemma":0.0007759195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002921887,"about_ca_topic_score_gemma":0.0005210504,"domain_scores_codex":[0.9993441,0.0001353025,0.00004727883,0.0001148841,0.0002580661,0.0001004004],"domain_scores_gemma":[0.9990056,0.0004856505,0.0000734537,0.000160352,0.0001139421,0.0001609418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008582913,0.00008810718,0.0006052273,0.0003440468,0.00005473329,0.003873263,0.0002807696,0.000674809,0.03338019,0.3190691,0.5486981,0.0920734],"study_design_scores_gemma":[0.0003601377,0.0002425134,0.0006832544,0.00007105972,0.00003726373,0.005128623,0.0002037015,0.002423696,0.01810521,0.2617286,0.7109281,0.00008771609],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01143693,0.01570397,0.007673783,0.9201365,0.02786326,0.00002079303,0.0001038745,0.0003480001,0.01671294],"genre_scores_gemma":[0.3407874,0.02133388,0.009750154,0.5060502,0.09223225,0.0001234075,0.000155399,0.0001866613,0.02938071],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.00637843,"threshold_uncertainty_score":0.01328045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006504126832962431,"score_gpt":0.2198248547425513,"score_spread":0.2133207279095888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}