{"id":"W1989577779","doi":"10.1016/j.cancergencyto.2004.05.005","title":"Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1","year":2005,"lang":"en","type":"article","venue":"Cancer Genetics and Cytogenetics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; McMaster University; Hôtel-Dieu de Québec; Hôpital Saint-François d'Assise","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Werner syndrome; Molecular biology; Poly ADP ribose polymerase; Helicase; Mutagenesis; Polymerase; Chromatid; Premature aging; Genetics; Genome instability; DNA repair; Mutation; Chromosome; DNA; Cell biology; Gene; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188622,0.0005240861,0.0003921743,0.001558147,0.0003045729,0.0004029423,0.000390135,0.0007539357,0.003465419],"category_scores_gemma":[0.0002236069,0.0004102861,0.0004390893,0.0004006216,0.0003447795,0.000265356,0.0004589567,0.001056293,0.0008379283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257334,"about_ca_system_score_gemma":0.0001816015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128053,"about_ca_topic_score_gemma":0.00149024,"domain_scores_codex":[0.9996221,0.00005902401,0.00004903599,0.0000918991,0.0001254436,0.00005248873],"domain_scores_gemma":[0.9992936,0.0001658797,0.0001690812,0.0001641203,0.00005722348,0.0001501472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007309088,0.0000128329,0.0003030671,0.00001334082,0.000009202737,0.0001254755,0.00001549779,0.00005366837,0.9984893,0.0001332724,0.00002766555,0.000743619],"study_design_scores_gemma":[0.00002593978,0.0002033052,0.01560647,0.000007017806,0.00004921492,0.001478198,0.00004722173,0.0007544561,0.9799308,0.0001031452,0.001784968,0.000009380192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985516,0.002335777,0.006889001,0.0001388519,0.0000501473,0.00003707284,0.001037774,0.0003142054,0.003681076],"genre_scores_gemma":[0.9881527,0.0007990063,0.002358713,0.00004455044,0.00001054065,0.00004037926,0.0009304331,0.00008276528,0.007580963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003465419,"threshold_uncertainty_score":0.01159298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149204764441117,"score_gpt":0.2739797843026271,"score_spread":0.2524877366582159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}