{"id":"W1989590412","doi":"10.1038/nature12873","title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","year":2013,"lang":"en","type":"review","venue":"Nature","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2473,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Key Research and Development Program of China; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Versus Arthritis; Assistance publique-Hôpitaux de Paris; Université Paris 13; Medical Research Council; Medical Research Council Canada; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China; Hanyang University; U.S. Public Health Service; Universiteit van Amsterdam; National Institutes of Health; Rijksuniversiteit Groningen; Ministry of Education, Culture, Sports, Science and Technology; School of Medicine, Boston University; Umeå Universitet; National Institute for Health and Care Research; U.S. National Library of Medicine; University of Pittsburgh; Institut National de la Santé et de la Recherche Médicale; Génome Québec; National Health and Medical Research Council; Université Paris-Sud; Brigham and Women's Hospital; McGill University; Japan Society for the Promotion of Science; GlaxoSmithKline","keywords":"Drug discovery; Rheumatoid arthritis; Computational biology; Drug; Biology; Medicine; Evolutionary biology; Genetics; Bioinformatics; Pharmacology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007343905,0.0009940838,0.001219687,0.001975191,0.0002503034,0.0008254786,0.0009591408,0.001322651,0.003991973],"category_scores_gemma":[0.001236451,0.0002754442,0.000439068,0.001686747,0.0007752333,0.000973438,0.0006915339,0.00207033,0.001678945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001069605,"about_ca_system_score_gemma":0.001637167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001643407,"about_ca_topic_score_gemma":0.004135814,"domain_scores_codex":[0.9997606,0.00004480228,0.00002443517,0.00003371729,0.0001093929,0.00002702597],"domain_scores_gemma":[0.9995117,0.0002662036,0.00005313486,0.00001511949,0.0001069411,0.00004684723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009484738,0.00006282284,0.0002158954,0.007814204,0.00008786155,0.0002438316,0.00002379793,0.0004142887,0.001707856,0.006410342,0.07156056,0.9113637],"study_design_scores_gemma":[0.00002813101,0.00004477494,0.000375678,0.001706671,0.0001142356,0.000714751,0.00002162968,0.00006577267,0.0002828209,0.003480624,0.9931531,0.00001179287],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007952187,0.996807,0.0002232555,0.0007209911,0.0005607693,0.000004079341,0.00002108071,0.00001195531,0.00157148],"genre_scores_gemma":[0.0006388613,0.9969618,0.0002681315,0.000579979,0.000569844,0.000005608062,0.00002910652,0.000001943506,0.0009448287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003991973,"threshold_uncertainty_score":0.01335442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176506773076267,"score_gpt":0.3702994118896645,"score_spread":0.3485343441589018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}