{"id":"W1989595797","doi":"10.1186/1479-5876-12-s1-p5","title":"Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-dependent advanced solid tumors: preliminary results","year":2014,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Maximum tolerated dose; Cancer research; Open label; Pharmacology; MEK inhibitor; Medicine; Oncology; Chemistry; Internal medicine; Adverse effect; MAPK/ERK pathway; Phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001455773,0.002382935,0.002447759,0.0006098917,0.0006306806,0.001272497,0.001295993,0.001851602,0.003520669],"category_scores_gemma":[0.0007800856,0.0009826795,0.001928209,0.0004796361,0.001340075,0.00113136,0.0004048561,0.005672895,0.001140054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001172434,"about_ca_system_score_gemma":0.001620476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001747728,"about_ca_topic_score_gemma":0.004317053,"domain_scores_codex":[0.9994691,0.0002195895,0.00001933313,0.0000875808,0.00005794846,0.0001464786],"domain_scores_gemma":[0.9992957,0.00009574929,0.0001028614,0.00006685589,0.00004216902,0.0003966393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5410807,0.1840255,0.004097962,0.0009228257,0.001668742,0.0004088103,0.000690108,0.00605196,0.1060753,0.0005910439,0.01112151,0.1432656],"study_design_scores_gemma":[0.4971235,0.4769787,0.01002579,0.00004520519,0.0004661821,0.0003642209,0.0001535749,0.002300525,0.007842781,0.0005082951,0.004129949,0.00006145197],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877701,0.002371532,0.00129847,0.0008254146,0.0001858871,0.002776386,0.001620094,0.0002428036,0.002909291],"genre_scores_gemma":[0.977805,0.002849846,0.004043147,0.001369801,0.0001913846,0.003720156,0.003670818,0.0001259424,0.00622385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003520669,"threshold_uncertainty_score":0.01177782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860309548580952,"score_gpt":0.3073482919107755,"score_spread":0.2887451964249659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}