{"id":"W1989595797","doi":"10.1186/1479-5876-12-s1-p5","title":"Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-dependent advanced solid tumors: preliminary results","year":2014,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Maximum tolerated dose; Cancer research; Open label; Pharmacology; MEK inhibitor; Medicine; Oncology; Chemistry; Internal medicine; Adverse effect; MAPK/ERK pathway; Phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107267,0.0002560177,0.0005473416,0.000321304,0.00008073609,0.00001594146,0.0002691313,0.0001281716,0.000006057946],"category_scores_gemma":[0.0001242466,0.0001896673,0.00002307094,0.0003178058,0.0000899897,0.0001689778,0.00003454726,0.000293374,1.812279e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004970381,"about_ca_system_score_gemma":0.0002405839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000862188,"about_ca_topic_score_gemma":0.00100807,"domain_scores_codex":[0.997151,0.0003803854,0.00106182,0.0003856728,0.0007982572,0.0002228758],"domain_scores_gemma":[0.9981705,0.00005162117,0.0007174842,0.0002269912,0.0006709567,0.0001624544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2305622,0.08562728,0.2094288,0.0001574617,0.0004480795,0.0001249654,0.01296289,0.01223833,0.3766763,0.0001958858,0.0002234555,0.07135429],"study_design_scores_gemma":[0.2124294,0.3380122,0.418372,0.0007325004,0.0001475785,0.00005882785,0.0009067313,0.001772402,0.02672761,0.0003098844,0.00008484082,0.0004459849],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977881,0.00005289771,0.0007247659,0.0002518936,0.0001288178,0.0009206656,0.00002459043,0.00000486286,0.000103411],"genre_scores_gemma":[0.9979624,0.000005333345,0.001303382,0.00006141534,0.0001855707,0.00001706124,0.0004187231,0.00002916143,0.00001693396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3499487,"threshold_uncertainty_score":0.7734409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860309548580952,"score_gpt":0.3073482919107755,"score_spread":0.2887451964249659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}