{"id":"W1989601885","doi":"10.1074/jbc.m112.350181","title":"Peroxisome Proliferator-activated Receptor γ Activation by Ligands and Dephosphorylation Induces Proprotein Convertase Subtilisin Kexin Type 9 and Low Density Lipoprotein Receptor Expression","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Tianjin Science and Technology Committee; National Natural Science Foundation of China; National Science Foundation","keywords":"PCSK9; LDL receptor; Proprotein convertase; Peroxisome proliferator-activated receptor; Kexin; Chemistry; Biology; Dephosphorylation; Endocrinology; Receptor; Internal medicine; Cell biology; Lipoprotein; Cholesterol; Phosphorylation; Biochemistry; Medicine; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854875,0.000444638,0.0003471088,0.000368571,0.0001880289,0.0003145162,0.0001128333,0.0002673915,0.001884084],"category_scores_gemma":[0.0001021117,0.0002854273,0.0005322219,0.0003056361,0.000294569,0.0001834299,0.000229206,0.0009268302,0.0006717975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316398,"about_ca_system_score_gemma":0.000308822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007475868,"about_ca_topic_score_gemma":0.001344678,"domain_scores_codex":[0.9997353,0.00003830233,0.00002859987,0.00004947339,0.00006594386,0.00008239281],"domain_scores_gemma":[0.9999156,0.00001187709,0.00002682759,0.00001155031,0.00001189489,0.00002220902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002971419,0.00003539227,0.0001577952,0.00005933357,0.000007416685,0.0000721442,0.00001576773,0.00003514543,0.9980952,0.00007340516,0.00004660948,0.00110483],"study_design_scores_gemma":[0.00003117204,0.0002827223,0.005499456,0.000009235701,0.00001584032,0.0002049351,0.00004611927,0.0003539949,0.9911965,0.00006757116,0.0022859,0.000006519381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873868,0.003583462,0.004517452,0.0002559018,0.00009723307,0.0000922787,0.0007464613,0.0001204598,0.003199995],"genre_scores_gemma":[0.9826858,0.003259463,0.003758563,0.0001677329,0.00002226174,0.0001284117,0.001405064,0.00002767291,0.008545056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884084,"threshold_uncertainty_score":0.006302834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209223949953592,"score_gpt":0.2324711476152678,"score_spread":0.2203789081157319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}