{"id":"W1989601885","doi":"10.1074/jbc.m112.350181","title":"Peroxisome Proliferator-activated Receptor γ Activation by Ligands and Dephosphorylation Induces Proprotein Convertase Subtilisin Kexin Type 9 and Low Density Lipoprotein Receptor Expression","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Tianjin Science and Technology Committee; National Natural Science Foundation of China; National Science Foundation","keywords":"PCSK9; LDL receptor; Proprotein convertase; Peroxisome proliferator-activated receptor; Kexin; Chemistry; Biology; Dephosphorylation; Endocrinology; Receptor; Internal medicine; Cell biology; Lipoprotein; Cholesterol; Phosphorylation; Biochemistry; Medicine; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005249603,0.0003458577,0.000394471,0.00004197164,0.0001544463,0.00006075669,0.0001645757,0.0007848768,0.00009445793],"category_scores_gemma":[0.0009388007,0.0002567495,0.00006979331,0.0001676961,0.0002037915,0.00007884147,0.000137792,0.0005078943,0.000003056704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007452224,"about_ca_system_score_gemma":0.0001107988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007230359,"about_ca_topic_score_gemma":1.644638e-7,"domain_scores_codex":[0.9983234,0.000126381,0.0005225465,0.0003880634,0.0002572806,0.0003823656],"domain_scores_gemma":[0.9984369,0.00003979128,0.0005591422,0.0001941814,0.0003770547,0.0003929244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351636,0.0002433007,0.01757662,0.00006450418,0.00006073149,6.812522e-7,0.00008129253,4.377783e-7,0.9780105,5.579306e-7,0.0009343611,0.001675356],"study_design_scores_gemma":[0.0008570467,0.0005077471,0.001596169,0.0001139926,0.00001258582,0.00004413186,0.0001540296,0.000002988864,0.9946849,0.000009512618,0.001689068,0.000327781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976001,0.001699951,0.00005734688,0.0001402586,0.0001382184,0.000306268,0.00002188617,0.00002098539,0.00001500827],"genre_scores_gemma":[0.9977753,0.000688287,0.0005689904,0.0001007365,0.0005766301,0.00002017311,0.0001719292,0.00002966237,0.00006827122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01667443,"threshold_uncertainty_score":0.9999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209223949953592,"score_gpt":0.2324711476152678,"score_spread":0.2203789081157319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}