{"id":"W1989603005","doi":"10.1074/jbc.m605718200","title":"A Hydrophobic Patch in a Charged α-Helix Is Sufficient to Target Proteins to Dense Core Secretory Granules","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Supramolecular Self-Assembly in Materials","field":"Materials Science","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Secretory protein; Granule (geology); Cell biology; Secretory pathway; Signal peptide; Organelle; Secretory Vesicle; Biology; Secretion; Enteroendocrine cell; Protein targeting; Cytoplasm; Endoplasmic reticulum; Biochemistry; Golgi apparatus; Peptide sequence; Chemistry; Membrane protein; Hormone; Endocrine system; Gene; Exocytosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002464231,0.000202561,0.0002257392,0.0001022064,0.000134196,0.0002595559,0.0001207005,0.0002630253,0.0007380831],"category_scores_gemma":[0.0003203248,0.0001311395,0.0001367981,0.0001063111,0.0003070239,0.0002090728,0.000146199,0.0003375261,0.0002316305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001941635,"about_ca_system_score_gemma":0.0001507093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001905428,"about_ca_topic_score_gemma":0.0003308907,"domain_scores_codex":[0.999809,0.00004555874,0.00002364386,0.00003002675,0.00005454586,0.00003724067],"domain_scores_gemma":[0.9995543,0.0001200569,0.0001032955,0.00004700686,0.00003817711,0.0001371134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008316331,0.00002339143,0.0001303137,0.00001760666,0.000004484303,0.00003220665,0.000004936921,0.0000858104,0.9991979,0.00004075304,0.00001035706,0.0003690825],"study_design_scores_gemma":[0.00002933463,0.0005346434,0.003117511,0.0000053641,0.00001494931,0.0004205932,0.00002152608,0.001079831,0.9937845,0.00005704239,0.0009307795,0.000003823286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974647,0.0004007391,0.001386945,0.00004011133,0.00001178807,0.00001547943,0.00004820002,0.00001941336,0.0006126768],"genre_scores_gemma":[0.9985256,0.0001352683,0.0008325355,0.00002892586,0.000005186784,0.00000713038,0.0001530179,0.000009242722,0.0003030293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007380831,"threshold_uncertainty_score":0.002469122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01877829694217358,"score_gpt":0.2538489355421951,"score_spread":0.2350706386000215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}