{"id":"W1989603885","doi":"10.1016/j.wem.2010.10.009","title":"Spironolactone Does Not Prevent Acute Mountain Sickness: A Prospective, Double-Blind, Randomized, Placebo-Controlled Trial by SPACE Trial Group (Spironolactone and Acetazolamide Trial in the Prevention of Acute Mountain Sickness Group)","year":2011,"lang":"en","type":"article","venue":"Wilderness and Environmental Medicine","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Wellcome Trust","keywords":"Spironolactone; Medicine; Acetazolamide; Placebo; Randomized controlled trial; Double blind; Anesthesia; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003144519,0.001440843,0.004440702,0.0005858953,0.0006696584,0.00149522,0.0009141262,0.003781196,0.005715221],"category_scores_gemma":[0.003372648,0.0007447784,0.002388,0.0004197173,0.001590303,0.001001945,0.0004778099,0.002365551,0.0009948057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004037153,"about_ca_system_score_gemma":0.001329319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006275657,"about_ca_topic_score_gemma":0.0009699085,"domain_scores_codex":[0.9983552,0.000962826,0.0001567842,0.0002420827,0.0001423348,0.0001407665],"domain_scores_gemma":[0.998285,0.0005045904,0.000468512,0.0001578685,0.0001586528,0.0004254219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9874422,0.003507025,0.0003354518,0.0007557757,0.0007377699,0.0000166998,0.00002722023,0.00006754615,0.001127408,0.00006141179,0.0002664828,0.005654849],"study_design_scores_gemma":[0.9744367,0.02445959,0.0005310581,0.00002197505,0.0001909072,0.000006345325,0.000005329915,0.00006880022,0.00009182987,0.00002478757,0.0001584917,0.00000412634],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617749,0.01744783,0.001234843,0.001588302,0.002613289,0.01145507,0.001345833,0.0002028934,0.002336926],"genre_scores_gemma":[0.964843,0.00783354,0.002326915,0.002309428,0.003108709,0.01485155,0.001114306,0.00002813959,0.003584282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005715221,"threshold_uncertainty_score":0.01911932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167597574464553,"score_gpt":0.2517052941381624,"score_spread":0.2400293183935169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}