{"id":"W1989603885","doi":"10.1016/j.wem.2010.10.009","title":"Spironolactone Does Not Prevent Acute Mountain Sickness: A Prospective, Double-Blind, Randomized, Placebo-Controlled Trial by SPACE Trial Group (Spironolactone and Acetazolamide Trial in the Prevention of Acute Mountain Sickness Group)","year":2011,"lang":"en","type":"article","venue":"Wilderness and Environmental Medicine","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Wellcome Trust","keywords":"Spironolactone; Medicine; Acetazolamide; Placebo; Randomized controlled trial; Double blind; Anesthesia; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001911606,0.00056538,0.001485336,0.0001188294,0.0001578635,0.00003472936,0.0003278689,0.0003548909,0.00008883692],"category_scores_gemma":[0.00004359288,0.000336885,0.0002500367,0.00007734542,0.0008945322,0.00005751866,0.0001970481,0.0003223305,0.000001548339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006207187,"about_ca_system_score_gemma":0.00002900291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005330119,"about_ca_topic_score_gemma":0.0002606965,"domain_scores_codex":[0.9965613,0.0005827941,0.00105637,0.0008257785,0.0005097612,0.0004639923],"domain_scores_gemma":[0.9986184,0.0001201367,0.0006028861,0.0004930056,0.00001224582,0.0001532896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.91932,0.001735078,0.0003765822,0.00003986638,0.0008515811,0.00001363551,0.001223593,9.914567e-7,0.07558469,0.0001883807,0.00002715939,0.0006384444],"study_design_scores_gemma":[0.9787659,0.00627768,0.0004492014,0.0000630078,0.001367605,0.00002157092,0.001100711,0.00004653188,0.01110492,0.0002509671,0.0001505845,0.0004012839],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851604,0.001094097,0.0009085,0.000292466,0.0003283134,0.01201455,0.00005207592,0.00001205358,0.0001375299],"genre_scores_gemma":[0.9936658,0.00212481,0.00008218986,0.0001067517,0.0006038005,0.002383619,0.0003675366,0.00004910905,0.0006164021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06447977,"threshold_uncertainty_score":0.9999083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167597574464553,"score_gpt":0.2517052941381624,"score_spread":0.2400293183935169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}