{"id":"W1989612486","doi":"10.1021/bi034163m","title":"Characterization of Two Independent Amino Acid Substitutions that Disrupt the DNA Repair Functions of the Yeast Apn1","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"AP endonuclease; AP site; DNA-(apurinic or apyrimidinic site) lyase; Endonuclease; Base excision repair; Biology; DNA; Biochemistry; Escherichia coli; DNA repair; DNA glycosylase; DNA damage; Mutant; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040129,0.0004428386,0.0002109032,0.000137919,0.00008978681,0.0001852238,0.0002758037,0.0002689307,0.0005141827],"category_scores_gemma":[0.000229468,0.0001337803,0.0002064175,0.0001941291,0.0001504784,0.0001168531,0.000162534,0.0003367849,0.0002904811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541087,"about_ca_system_score_gemma":0.0001560637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009306042,"about_ca_topic_score_gemma":0.0007298979,"domain_scores_codex":[0.9999019,0.00001480852,0.00001372308,0.00002093706,0.00003704247,0.00001157684],"domain_scores_gemma":[0.9998358,0.00003134479,0.00007149184,0.00001505308,0.00001795317,0.00002823664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007097379,0.00003846062,0.0004832368,0.00002849469,0.000008572105,0.0001185383,0.00001628657,0.0002170423,0.9979449,0.00005998776,0.00001460416,0.0009988369],"study_design_scores_gemma":[0.00002636201,0.0002775177,0.01160877,0.000006758285,0.00003336823,0.001181597,0.00005368865,0.002229888,0.9817924,0.00004919362,0.002730984,0.000009530455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971824,0.000365297,0.001710662,0.00002852107,0.000008741929,0.00001750724,0.000413763,0.00002205384,0.0002510121],"genre_scores_gemma":[0.9942195,0.0003748203,0.002922799,0.00002795712,0.000004281191,0.00002289011,0.001595401,0.00003695444,0.0007954233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009306042,"threshold_uncertainty_score":0.001850367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025212806616898,"score_gpt":0.223521342057118,"score_spread":0.213269213990949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}