{"id":"W1989649735","doi":"10.1016/j.schres.2010.02.688","title":"PARTIAL AGONISTS IN SCHIZOPHRENIA – WHY SOME SUCCEED AND OTHERS DON'T. INSIGHTS FROM PRECLINICAL COMPARISONS","year":2010,"lang":"en","type":"article","venue":"Schizophrenia Research","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Tacrine; Pindolol; Chemistry; Pharmacology; Mecamylamine; Agonist; Endocrinology; Cholinergic; Internal medicine; Muscarinic acetylcholine receptor; Medicine; Receptor; Biochemistry; Acetylcholinesterase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00188391,0.0003828643,0.0009033009,0.0004090351,0.0003205026,0.0007541206,0.0005094651,0.0008369795,0.00305325],"category_scores_gemma":[0.001020007,0.0001569919,0.0003912434,0.0002927436,0.001358087,0.00158836,0.0004608176,0.001325135,0.0006890039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004069159,"about_ca_system_score_gemma":0.0007484583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006876185,"about_ca_topic_score_gemma":0.002591259,"domain_scores_codex":[0.9996785,0.0001500815,0.00004418911,0.00002676443,0.00004742007,0.00005306639],"domain_scores_gemma":[0.9992003,0.0002578976,0.0001671328,0.0001079348,0.00008980164,0.0001770031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04567216,0.003834328,0.02135428,0.002398887,0.001276903,0.001264528,0.0009352876,0.0007022653,0.07958502,0.02609919,0.01064597,0.8062312],"study_design_scores_gemma":[0.01738695,0.2670224,0.2602187,0.004362196,0.005245732,0.007387355,0.008438368,0.001722456,0.04783726,0.09629077,0.2836394,0.0004483864],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6873053,0.2749035,0.0004452181,0.01830751,0.0007055881,0.0001119425,0.0006618429,0.00004986974,0.01750922],"genre_scores_gemma":[0.862801,0.1288325,0.0005441531,0.004632711,0.0006002404,0.00006147757,0.00039769,0.00001599495,0.002114394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00305325,"threshold_uncertainty_score":0.01021415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09029473966339743,"score_gpt":0.4202945193897085,"score_spread":0.329999779726311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}