{"id":"W1989652867","doi":"10.1038/nsb1014","title":"Germline antibody recognition of distinct carbohydrate epitopes","year":2003,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria; Institute for Biological Sciences; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; University of Alberta; Austrian Science Fund; University of Ottawa; U.S. Department of Energy","keywords":"Epitope; Germline; Complementarity determining region; Biology; Immunogen; Antibody; Computational biology; Antigen; Genetics; Gene; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001835106,0.0002127286,0.0002338946,0.0001024202,0.00007112225,0.00001230679,0.0002056938,0.0005890245,0.0001288829],"category_scores_gemma":[0.0005492809,0.0001773461,0.0001456755,0.0002166104,0.0001787028,0.000004080583,0.00007111985,0.0003556612,0.000007961359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001162459,"about_ca_system_score_gemma":0.00007786681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002789349,"about_ca_topic_score_gemma":0.0000186422,"domain_scores_codex":[0.9985141,0.000285427,0.0002827705,0.0004420924,0.0001430476,0.0003326247],"domain_scores_gemma":[0.9991229,0.00001211987,0.0001307279,0.0003604512,0.0002813653,0.0000925012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007771881,0.00001273998,0.002251775,0.00001828971,0.00005777446,0.000008763693,0.000006159068,0.000008848534,0.9915612,0.002574468,0.00005219108,0.003370073],"study_design_scores_gemma":[0.0006405775,0.0003276941,0.005250727,0.000009142937,0.0000169618,0.00004367272,0.00001010274,0.00003397623,0.9804843,0.00380777,0.009133196,0.0002418433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932617,0.002289829,0.002136943,0.0001676552,0.0002920439,0.0002910696,0.00009568517,0.00001395316,0.001451098],"genre_scores_gemma":[0.9962793,0.00005316343,0.00182441,0.0002416837,0.00009544957,0.00001201069,0.00136504,0.00002285649,0.0001060597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01107686,"threshold_uncertainty_score":0.7231963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006952888692834327,"score_gpt":0.3275555254165037,"score_spread":0.3206026367236693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}