{"id":"W1989660004","doi":"10.1074/jbc.m109.037085","title":"Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Sherbrooke; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"PCSK9; Endogeny; LDL receptor; Receptor; Degradation (telecommunications); Cell biology; Chemistry; Lipoprotein; Cholesterol; Biochemistry; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529094,0.0002513861,0.0002120648,0.000193763,0.00017188,0.0004260604,0.0001769512,0.000213951,0.0009074913],"category_scores_gemma":[0.0001072209,0.0001527954,0.0003042232,0.0001063614,0.0002174293,0.0002310872,0.0001624564,0.0007269335,0.0005695639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007657004,"about_ca_system_score_gemma":0.0003473109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008597546,"about_ca_topic_score_gemma":0.0009397456,"domain_scores_codex":[0.9998524,0.00002670694,0.00001766457,0.00002776383,0.00004080969,0.00003470284],"domain_scores_gemma":[0.9998997,0.00002337409,0.00002224877,0.00002062672,0.00001232134,0.0000216586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002169935,0.00002869253,0.0001410928,0.00004354916,0.000005361623,0.00005531136,0.000009622733,0.00009086417,0.9981002,0.0003477539,0.00002881444,0.0009317091],"study_design_scores_gemma":[0.00001268295,0.00007843502,0.001637311,0.000002772191,0.000007653448,0.00009860987,0.0000114143,0.001008823,0.9957931,0.00003818038,0.001308483,0.000002519081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823619,0.002977681,0.01021539,0.0002186877,0.00007281018,0.00006991358,0.0009994559,0.000144251,0.002939994],"genre_scores_gemma":[0.9891249,0.001653659,0.004761794,0.00005731454,0.00001707687,0.00007351168,0.000693172,0.00003064756,0.003587876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009074913,"threshold_uncertainty_score":0.00555557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03693823842091521,"score_gpt":0.2331007440949782,"score_spread":0.196162505674063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}