{"id":"W1989683475","doi":"10.1158/1078-0432.ccr-04-1399","title":"Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Biology; In vivo; NAD+ kinase; Apoptosis; Phosphocholine; Cancer research; Mammary tumor; Bioenergetics; Programmed cell death; Biochemistry; Phospholipid; Mitochondrion; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004778852,0.0004158161,0.001330074,0.0003418667,0.0003770164,0.0001166272,0.0005392839,0.0004391551,0.002212502],"category_scores_gemma":[0.00658573,0.0002880905,0.0002927858,0.001465883,0.000925327,0.0001412404,0.00016129,0.002895471,0.000129547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003967526,"about_ca_system_score_gemma":0.0009900619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006450883,"about_ca_topic_score_gemma":0.0006609394,"domain_scores_codex":[0.9929882,0.0008454953,0.00113426,0.001176805,0.002482275,0.001373026],"domain_scores_gemma":[0.9942964,0.002799254,0.0002165932,0.0009284975,0.0009137391,0.000845506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009912292,0.00392333,0.04910732,0.0002525426,0.000967512,0.0003648215,0.0003176815,0.00001409024,0.3427469,0.0001276011,0.4524553,0.1398107],"study_design_scores_gemma":[0.0200015,0.008260278,0.2543561,0.004269635,0.00129377,0.00002926666,0.0005877047,0.002078906,0.5141596,0.0001132112,0.1934613,0.001388726],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463018,0.04113091,0.000007334212,0.009273055,0.0005528753,0.001171054,0.00006558266,0.0001303471,0.001367053],"genre_scores_gemma":[0.98329,0.005820884,0.0003036527,0.002042166,0.003063385,0.000586248,0.0000263634,0.0001210925,0.004746271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.258994,"threshold_uncertainty_score":0.9999571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08103890061726868,"score_gpt":0.444796569088189,"score_spread":0.3637576684709204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}