{"id":"W1989686048","doi":"10.1016/j.chembiol.2012.11.011","title":"Deglycosylation as a Mechanism of Inducible Antibiotic Resistance Revealed Using a Global Relational Tree for One-Component Regulators","year":2013,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"TetR; Biology; Transcription factor; Phylogenomics; Mechanism (biology); Gene; Computational biology; Antibiotic resistance; Tree of life (biology); Repressor; Genetics; Antibiotics; Phylogenetic tree","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189705,0.0001652667,0.0002364153,0.00001469485,0.00008601148,0.000006975907,0.0001480335,0.0002727428,0.00002309447],"category_scores_gemma":[0.0001179373,0.0001706348,0.0001102136,0.00007806023,0.0001166715,0.000001462683,0.00009392121,0.00004536846,0.000002872859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004201291,"about_ca_system_score_gemma":0.0001047694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004638998,"about_ca_topic_score_gemma":0.00001141993,"domain_scores_codex":[0.9989399,0.00002624552,0.0003209066,0.0004071548,0.0000643653,0.0002414386],"domain_scores_gemma":[0.9991985,0.00002202791,0.0002199384,0.0003036429,0.0001959507,0.00005991678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007615665,0.00004596265,0.004952115,0.00006157015,0.00009974174,1.305499e-7,0.00001285649,0.00001879229,0.9922846,0.002119755,0.0001101926,0.0002181073],"study_design_scores_gemma":[0.0007659396,0.0001211556,0.01452937,0.00003369301,0.00004880839,0.00001052609,0.00004140628,0.0001937611,0.9681695,0.01452838,0.001320355,0.0002371376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953371,0.0008577569,0.001945172,0.0001239326,0.00009247492,0.0003245157,0.00007768448,0.000004544806,0.001236765],"genre_scores_gemma":[0.9902765,0.00005634542,0.008948217,0.00004539792,0.0001626507,0.00002409406,0.0001729607,0.00001399896,0.0002998622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02411515,"threshold_uncertainty_score":0.6958287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269098302724791,"score_gpt":0.255493003648993,"score_spread":0.2328020206217451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}