{"id":"W1989699558","doi":"10.3389/fphar.2011.00051","title":"From Understanding Cellular Function to Novel Drug Discovery: The Role of Planar Patch-Clamp Array Chip Technology","year":2011,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Ottawa; Institute for Microstructural Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Ion channel; Patch clamp; Electrophysiology; Drug discovery; Nanotechnology; Microfluidics; Computer science; Materials science; Multielectrode array; Neuroscience; Chemistry; Microelectrode; Biology; Electrode","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001259716,0.0006813993,0.001729541,0.0008611378,0.0001989225,0.002039197,0.001516528,0.001244446,0.0009538289],"category_scores_gemma":[0.001062959,0.0006250237,0.0007005482,0.0006735143,0.001345973,0.002796787,0.0009190154,0.003254627,0.001311613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009800979,"about_ca_system_score_gemma":0.0005792382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677046,"about_ca_topic_score_gemma":0.0003876843,"domain_scores_codex":[0.9993869,0.0001062974,0.00005294977,0.0001654004,0.0002391549,0.00004932968],"domain_scores_gemma":[0.9995055,0.000260026,0.00003972582,0.00004665211,0.0001121027,0.00003596213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421111,0.0001572352,0.0007671202,0.005757211,0.0003017535,0.0004748037,0.0003366882,0.007637306,0.4121403,0.06541771,0.01533184,0.4914359],"study_design_scores_gemma":[0.00009463365,0.001263763,0.001962104,0.001029343,0.0004111884,0.002493525,0.0002340513,0.02585664,0.3418276,0.0517002,0.5727748,0.0003520684],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01351367,0.6703515,0.295143,0.005472467,0.00109273,0.0002244904,0.0006367162,0.002006383,0.01155901],"genre_scores_gemma":[0.09109496,0.6676112,0.2280042,0.004661694,0.001057579,0.0004562581,0.0009022494,0.0002230336,0.0059888],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002039197,"threshold_uncertainty_score":0.007111132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421344391453005,"score_gpt":0.2362064633337226,"score_spread":0.2019930194191926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}