{"id":"W1989715997","doi":"10.1158/0008-5472.can-09-0342","title":"Multipotent CD15+ Cancer Stem Cells in <i>Patched-1</i> –Deficient Mouse Medulloblastoma","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Hospital for Sick Children; Ontario Genomics Institute; Stem Cell Network; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Patched; Cancer stem cell; Clonogenic assay; Cancer research; Biology; Medulloblastoma; Cancer; Stem cell; CD15; Cancer cell; Wnt signaling pathway; Hedgehog signaling pathway; Immunology; Cell biology; In vitro; Signal transduction; CD34; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007277226,0.0002066535,0.0002373513,0.0001558738,0.0001520222,0.00003902589,0.0004117975,0.0001674127,0.00003452033],"category_scores_gemma":[0.00004102611,0.0001915199,0.00008336869,0.0004039853,0.0002073771,0.000004360072,0.0002043114,0.0003659475,0.00003654465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253525,"about_ca_system_score_gemma":0.0003596403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000535517,"about_ca_topic_score_gemma":0.001056551,"domain_scores_codex":[0.9974806,0.0001999436,0.0002835975,0.0006527507,0.0005516283,0.0008314237],"domain_scores_gemma":[0.9989727,0.00002890059,0.0000488235,0.0004713249,0.0003104312,0.0001678017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000153996,0.0001380676,0.000949186,0.00003023835,0.0000270036,0.00001924849,0.0003941584,0.001890299,0.9786344,0.00001401245,0.005827869,0.01192148],"study_design_scores_gemma":[0.0007462777,0.0002861087,0.0007080446,0.00007243903,0.000004466959,0.000001210424,0.0005094513,0.0000910124,0.9702872,0.00001205254,0.0270574,0.0002243498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909311,0.006783265,0.00005882928,0.001032914,0.0001920817,0.0005145862,0.00008024596,0.00002191749,0.0003850959],"genre_scores_gemma":[0.9935375,0.002524136,0.00005736207,0.0003810209,0.0002806693,0.0003263885,0.000007993242,0.00003193201,0.002852931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02122953,"threshold_uncertainty_score":0.7809955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0619287701577962,"score_gpt":0.3723790747872186,"score_spread":0.3104503046294224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}