{"id":"W1989715997","doi":"10.1158/0008-5472.can-09-0342","title":"Multipotent CD15+ Cancer Stem Cells in <i>Patched-1</i> –Deficient Mouse Medulloblastoma","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Hospital for Sick Children; Ontario Genomics Institute; Stem Cell Network; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Patched; Cancer stem cell; Clonogenic assay; Cancer research; Biology; Medulloblastoma; Cancer; Stem cell; CD15; Cancer cell; Wnt signaling pathway; Hedgehog signaling pathway; Immunology; Cell biology; In vitro; Signal transduction; CD34; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143253,0.0002374622,0.0001800599,0.0006651151,0.0001747633,0.0002846069,0.0001160404,0.0001642689,0.001063971],"category_scores_gemma":[0.00007362854,0.0001753224,0.0001586364,0.0001531597,0.0002206461,0.000216019,0.0001865613,0.0004095893,0.0003566899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002282932,"about_ca_system_score_gemma":0.0001379799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009387357,"about_ca_topic_score_gemma":0.001756934,"domain_scores_codex":[0.9998735,0.00001324206,0.0000181669,0.00002884987,0.00003631995,0.00002992257],"domain_scores_gemma":[0.9998841,0.00001098886,0.00002801484,0.00001214339,0.00001107016,0.00005362676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004152901,0.000009251736,0.0003410385,0.000008055506,0.000002034367,0.00003489088,0.00002062439,0.00002894681,0.9989532,0.0001107078,0.00001186872,0.0004377297],"study_design_scores_gemma":[0.00001013266,0.0001317376,0.004370186,0.000004856855,0.00001331546,0.0004173799,0.00003555262,0.00053816,0.9932135,0.0000634984,0.001199442,0.000002155204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957558,0.000540772,0.001990423,0.00003887345,0.0000102753,0.0000213808,0.000301226,0.00007372707,0.001267538],"genre_scores_gemma":[0.9929004,0.0004038583,0.002785739,0.00002206995,0.000005342008,0.00002410604,0.0004914322,0.00003097036,0.003336139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063971,"threshold_uncertainty_score":0.003559351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0619287701577962,"score_gpt":0.3723790747872186,"score_spread":0.3104503046294224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}