{"id":"W1989724385","doi":"10.1021/jm060369k","title":"Replacement of the<i>N</i>-terminal Tyrosine Residue in Opioid Peptides with 3-(2,6-Dimethyl-4-carbamoylphenyl)propanoic Acid (Dcp) Results in Novel Opioid Antagonists","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Propanoic acid; Residue (chemistry); Tyrosine; Opioid; Opioid peptide; Stereochemistry; Pharmacology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000771865,0.0002211546,0.0002103318,0.00006070805,0.000101566,0.0001940371,0.0002261841,0.0002032,0.0004330746],"category_scores_gemma":[0.0001013972,0.0001165791,0.0001379103,0.00007278503,0.0001782677,0.000144161,0.0001077318,0.0003754051,0.0001916484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284792,"about_ca_system_score_gemma":0.0002029574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003879388,"about_ca_topic_score_gemma":0.000516013,"domain_scores_codex":[0.9999317,0.000008651272,0.000006615092,0.0000161839,0.00001863565,0.00001828357],"domain_scores_gemma":[0.9999276,0.000008724554,0.00002784112,0.000006292463,0.000007609466,0.00002177075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009425812,0.00001347857,0.00007447257,0.00001524624,0.000002739328,0.00006569724,0.000006356186,0.00009745009,0.9983987,0.0001072507,0.00001357276,0.001110733],"study_design_scores_gemma":[0.00002753369,0.0005084866,0.001101729,0.000002396227,0.00001442329,0.0003646721,0.000008415702,0.0004236716,0.9955232,0.0000232339,0.001997679,0.000004432949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956954,0.0008483834,0.002234284,0.00005387337,0.00002166314,0.00002406835,0.0001350279,0.00003214994,0.0009551384],"genre_scores_gemma":[0.9944029,0.0006801406,0.003545833,0.00003790679,0.00001060057,0.00001826009,0.0002299046,0.000009995326,0.001064549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004330746,"threshold_uncertainty_score":0.001657724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372204557895102,"score_gpt":0.242092166047825,"score_spread":0.228370120468874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}