{"id":"W1989726000","doi":"10.1371/journal.pone.0085502","title":"The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"HES1; Notch signaling pathway; MAPK/ERK pathway; Cell biology; Signal transduction; Intracellular; Hes3 signaling axis; MEK inhibitor; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006253481,0.0001746604,0.0001301421,0.0001068182,0.00011529,0.0002112832,0.00008703356,0.000079563,0.001563055],"category_scores_gemma":[0.00004478512,0.00009278937,0.000133717,0.0001130634,0.00008192136,0.0001149533,0.000156974,0.0002827578,0.0004328332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977604,"about_ca_system_score_gemma":0.0001953527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005639013,"about_ca_topic_score_gemma":0.0008745568,"domain_scores_codex":[0.9999443,0.000008384679,0.000004030559,0.00001040359,0.00001810619,0.00001465596],"domain_scores_gemma":[0.9999834,0.000002533129,0.000003162831,0.000002278176,0.000003390499,0.000005194986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002284753,0.00003490139,0.000281891,0.0000842536,0.000005529858,0.00008841776,0.00002339906,0.00009605056,0.9958718,0.0002542228,0.00009693572,0.002933969],"study_design_scores_gemma":[0.00002166752,0.0001397262,0.007805022,0.000006645419,0.00001256912,0.0003493997,0.00003636567,0.001307287,0.9831476,0.0001192535,0.007050308,0.000004164614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865263,0.003090495,0.002494243,0.0001533706,0.00003432186,0.00002100828,0.0004919596,0.0001082722,0.007080025],"genre_scores_gemma":[0.99119,0.001557841,0.001351725,0.00003922054,0.000006915559,0.00002143729,0.0004129751,0.000008999303,0.00541082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563055,"threshold_uncertainty_score":0.005228877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416089847486277,"score_gpt":0.2001246559914213,"score_spread":0.1859637575165585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}