{"id":"W1989738561","doi":"10.1038/sj.onc.1207004","title":"Role of the TRAIL/APO2-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemia","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Research Manitoba","funders":"CancerCare Manitoba Foundation; Leukemia and Lymphoma Society; Friedreich's Ataxia Research Alliance","keywords":"Chronic lymphocytic leukemia; Apoptosis; Chlorambucil; Fludarabine; Biology; Cancer research; Programmed cell death; Receptor; Leukemia; Downregulation and upregulation; Immunology; Chemotherapy; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908502,0.0001226196,0.000150141,0.00005068459,0.00003199414,0.00000714679,0.0000954697,0.000172356,0.00001566316],"category_scores_gemma":[0.00003270265,0.00009660876,0.00005609555,0.0001647651,0.00002892609,0.000003412179,0.00004060481,0.00005886579,0.000001160925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005214446,"about_ca_system_score_gemma":0.0006056315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002077633,"about_ca_topic_score_gemma":0.0004538285,"domain_scores_codex":[0.9991862,0.00006787235,0.0002154809,0.0002504427,0.00009461492,0.0001853859],"domain_scores_gemma":[0.9996262,0.000006393707,0.00007009604,0.000237741,0.00002162426,0.00003795405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002032816,0.00001261,0.0009437116,0.00001318001,0.000008762692,2.993925e-7,0.00006027702,0.0007847848,0.9896588,0.000248146,0.000008256876,0.00824088],"study_design_scores_gemma":[0.001059946,0.0001312081,0.003058912,0.00003114905,0.0000102399,0.000006884371,0.00006916284,0.0005759499,0.9904276,0.0002450696,0.004261538,0.0001223818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969993,0.001816619,0.0000228118,0.00001516547,0.0001049552,0.0001968729,0.000002513584,0.000003164187,0.0008385697],"genre_scores_gemma":[0.9989377,0.0005067988,0.0001611779,0.00002731538,0.00004358632,0.00001680943,0.00001249132,0.00001547716,0.0002786482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008118498,"threshold_uncertainty_score":0.3939591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009212524020337662,"score_gpt":0.2257852995986937,"score_spread":0.216572775578356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}