{"id":"W1989753758","doi":"10.1089/hum.2008.131","title":"Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Small interfering RNA; RNA interference; Immune system; Biology; Innate immune system; Interferon; In vivo; Immunology; Cancer research; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154844,0.0001654351,0.0001598876,0.00003090242,0.0001550474,0.00001321806,0.0002919331,0.00008416152,0.00002487105],"category_scores_gemma":[0.000009736019,0.0001234857,0.0001251803,0.00004880618,0.0001058166,0.00000373683,0.00005214826,0.00008577975,0.000004754654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001024488,"about_ca_system_score_gemma":0.00001922812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004874464,"about_ca_topic_score_gemma":0.000006693921,"domain_scores_codex":[0.9991534,0.00009628187,0.0002496231,0.0002254358,0.00009091574,0.0001843458],"domain_scores_gemma":[0.9993643,0.00002768463,0.0001257053,0.0003881226,0.00006724296,0.00002689883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009770584,0.00005257601,0.0007322779,0.000009876808,0.000121248,0.000002149677,0.0006183006,0.00008166082,0.9940228,0.000004424317,0.0001842404,0.004072678],"study_design_scores_gemma":[0.0006609598,0.0007161287,0.007540692,0.00002886753,0.00001045686,0.000008593471,0.00003424856,0.0001150327,0.9902216,0.00003518185,0.0004861192,0.0001421501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888198,0.007815505,0.002782079,0.00002663256,0.0001203629,0.0002270135,0.000002494279,0.00001370123,0.0001924231],"genre_scores_gemma":[0.9980345,0.001028766,0.00004232,0.0002480226,0.0001133402,0.00001876079,0.00004195792,0.00002783586,0.0004445122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009214696,"threshold_uncertainty_score":0.5035601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208646026892914,"score_gpt":0.2536930695810322,"score_spread":0.2328284668917407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}