{"id":"W1989753758","doi":"10.1089/hum.2008.131","title":"Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Small interfering RNA; RNA interference; Immune system; Biology; Innate immune system; Interferon; In vivo; Immunology; Cancer research; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00973086,0.001009722,0.0008744356,0.001328037,0.0004704348,0.001771057,0.001135823,0.001899386,0.0006519284],"category_scores_gemma":[0.01078353,0.0004580744,0.0007900172,0.000451552,0.002811069,0.00136653,0.001093238,0.00263365,0.0005849757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007897075,"about_ca_system_score_gemma":0.0003601285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926321,"about_ca_topic_score_gemma":0.0002483842,"domain_scores_codex":[0.9915383,0.00378689,0.001387423,0.000766733,0.002324151,0.0001965555],"domain_scores_gemma":[0.9876311,0.008311013,0.001394179,0.001160687,0.00134916,0.0001537867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003934434,0.00007420338,0.00313466,0.001635902,0.0001481534,0.002154281,0.0009173527,0.0009727302,0.923124,0.01073496,0.00238745,0.05432284],"study_design_scores_gemma":[0.00004253124,0.0006873457,0.004564676,0.0002699474,0.0002579398,0.008691787,0.0004096062,0.004337895,0.9313843,0.009493797,0.03980004,0.00006020548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4708008,0.1342116,0.3400653,0.02134868,0.01127577,0.0004435911,0.0004356273,0.002826813,0.01859168],"genre_scores_gemma":[0.8741618,0.02199064,0.08386656,0.01352822,0.001883818,0.0003030381,0.0002374741,0.000543833,0.003484614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00973086,"threshold_uncertainty_score":0.05146235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208646026892914,"score_gpt":0.2536930695810322,"score_spread":0.2328284668917407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}