{"id":"W1989769800","doi":"10.1016/j.bmcl.2009.08.014","title":"Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Hydrazine (antidepressant); CXC chemokine receptors; Chemotaxis; Ene reaction; Chemokine receptor; Stereochemistry; Chemical synthesis; Receptor; Chemokine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223078,0.0004683278,0.0004318005,0.0002353812,0.0001698636,0.0003270803,0.000460968,0.0002356374,0.002017261],"category_scores_gemma":[0.0001381118,0.0002321944,0.0001900279,0.000176288,0.0001855614,0.0002001791,0.0002112723,0.0004060502,0.0004856678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369538,"about_ca_system_score_gemma":0.000366967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008193345,"about_ca_topic_score_gemma":0.003275423,"domain_scores_codex":[0.9999006,0.00001760508,0.000008424001,0.00001382532,0.00002328831,0.00003621461],"domain_scores_gemma":[0.9999555,0.000004835788,0.00001151108,0.000004014576,0.00000916003,0.00001488186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000701192,0.0002464489,0.0002731408,0.0003555041,0.00002975862,0.0003013652,0.00008239203,0.002053124,0.9688465,0.0009384266,0.0006703713,0.02550176],"study_design_scores_gemma":[0.0009484899,0.005125252,0.002506782,0.00004328724,0.0001164061,0.0007301296,0.00005766914,0.002862115,0.9595878,0.0001949893,0.02777785,0.0000491825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951817,0.01983559,0.01453239,0.0005369282,0.0002886693,0.0008920705,0.001176167,0.0002462049,0.01067492],"genre_scores_gemma":[0.9668245,0.01180119,0.01063977,0.0002534506,0.00005361353,0.0002906344,0.0009805368,0.00002805169,0.009128275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002017261,"threshold_uncertainty_score":0.006748378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02413522889673007,"score_gpt":0.2740413730877557,"score_spread":0.2499061441910257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}