{"id":"W1989773068","doi":"10.1073/pnas.0900562106","title":"Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Kinase; EIF4E; MAPK/ERK pathway; Biology; Cell biology; Translation (biology); Gene knockdown; Phosphorylation; Protein kinase A; Cancer research; Gene; Messenger RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008716256,0.00004783988,0.0001071001,0.0001942738,0.00004799448,0.000006040958,0.0001455255,0.00004198418,0.000005887602],"category_scores_gemma":[0.0007315165,0.00002816076,0.00002917007,0.0003945806,0.0001343937,0.0002467626,0.00002170678,0.000114003,1.20941e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002019656,"about_ca_system_score_gemma":0.00003586023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009986312,"about_ca_topic_score_gemma":1.557122e-7,"domain_scores_codex":[0.9990099,0.00001024965,0.0002745526,0.0001014103,0.0005519085,0.00005197929],"domain_scores_gemma":[0.9992344,0.00009052825,0.0002947336,0.00000652717,0.0003632121,0.00001058096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258283,0.00007257718,0.001843884,0.00002853987,0.000004325952,2.552442e-9,0.0006695596,0.00001888995,0.9880441,0.008841988,0.0001250528,0.0002252136],"study_design_scores_gemma":[0.0001583161,0.0003398613,0.09686279,0.0001709656,0.00000933889,0.000005266533,0.0003820972,0.000880347,0.8984924,0.002660283,0.00001542395,0.00002293449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953234,0.0001087399,6.704934e-7,0.003032827,0.00001217691,0.000139266,0.000003698393,0.000002248971,0.001377017],"genre_scores_gemma":[0.9995817,0.00003198834,0.0001118171,0.0001711979,0.00006330934,0.000002138018,2.389987e-7,0.000001410564,0.00003622347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0950189,"threshold_uncertainty_score":0.1148363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0805210234430362,"score_gpt":0.3349776069137338,"score_spread":0.2544565834706977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}