{"id":"W1989803279","doi":"10.1038/sj.leu.2405087","title":"Efficacy and safety of bortezomib in patients with renal impairment: results from the APEX phase 3 study","year":2008,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Bortezomib; Medicine; Dexamethasone; Multiple myeloma; Renal function; Internal medicine; Creatinine; Adverse effect; Proteasome inhibitor; Urology; Phases of clinical research; Gastroenterology; Toxicity; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002284553,0.0008462561,0.002862371,0.0002657576,0.0003438811,0.00128352,0.0005888768,0.00065703,0.001747889],"category_scores_gemma":[0.001421498,0.0002978145,0.001835281,0.0004399417,0.0006266575,0.0007550472,0.0004422615,0.002180708,0.0003821178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008984893,"about_ca_system_score_gemma":0.001216158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009166067,"about_ca_topic_score_gemma":0.001533555,"domain_scores_codex":[0.9994166,0.0002288433,0.00003887567,0.00007702928,0.0001343414,0.0001043382],"domain_scores_gemma":[0.9984015,0.0004297514,0.0004586418,0.0001567898,0.0001399082,0.0004132937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8118904,0.004670781,0.04931185,0.0007130112,0.005163694,0.0002493056,0.0001834982,0.002006693,0.01914076,0.000332152,0.003345356,0.1029925],"study_design_scores_gemma":[0.5637413,0.1545825,0.2563437,0.0001728843,0.006673322,0.0009701384,0.0002042822,0.001914553,0.006774136,0.0009317405,0.007581412,0.0001099184],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888499,0.007823729,0.0002136714,0.0003169795,0.00004321729,0.0001497961,0.001049819,0.00003276367,0.001520058],"genre_scores_gemma":[0.9922936,0.003087379,0.000543001,0.0006035333,0.0001349502,0.0001434744,0.002528072,0.00002415561,0.0006418001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002862371,"threshold_uncertainty_score":0.01208204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932933302448729,"score_gpt":0.2877653199784997,"score_spread":0.2684359869540124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}