{"id":"W1989820173","doi":"10.1371/journal.pone.0066316","title":"A Mechanistic Study on the Destabilization of Whole Inactivated Influenza Virus Vaccine in Gastric Environment","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; National Institute for Nanotechnology","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Georgia State University; University of Cincinnati; Bill and Melinda Gates Foundation","keywords":"Osmotic shock; Osmotic pressure; Biophysics; Hemagglutination assay; Osmotic concentration; Dynamic light scattering; Chemistry; Virus; Microbiology; Influenza vaccine; Virology; Biology; Biochemistry; Materials science; Nanoparticle; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000278332,0.0003982372,0.0003257006,0.00008201359,0.0001642285,0.0002461974,0.0002354467,0.0003607962,0.0007500688],"category_scores_gemma":[0.0002289695,0.0001185692,0.0003502638,0.0000598503,0.0003048475,0.000483184,0.0002156032,0.000471304,0.0001426167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017082,"about_ca_system_score_gemma":0.0001433774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002579968,"about_ca_topic_score_gemma":0.0002423208,"domain_scores_codex":[0.999891,0.00002447237,0.000004872462,0.00002681204,0.00002400846,0.00002881537],"domain_scores_gemma":[0.999911,0.00002636722,0.00002931848,0.000008152037,0.0000164533,0.000008696223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005997003,0.00001874591,0.0001567858,0.00009287091,0.00001153893,0.0000438469,0.00002256576,0.0001521876,0.9979201,0.0001560281,0.00002032047,0.001345158],"study_design_scores_gemma":[0.000006094708,0.000564464,0.002252849,0.000007680209,0.00002547364,0.0001703083,0.00004162388,0.0015652,0.9939809,0.0001426391,0.001234861,0.000008063903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812414,0.00650131,0.01059561,0.0002793462,0.00007086668,0.00007345962,0.0001569572,0.00003407242,0.001047082],"genre_scores_gemma":[0.9931719,0.00284449,0.002924865,0.0001032924,0.00001930926,0.00003276423,0.0001323409,0.00000740599,0.0007636212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007500688,"threshold_uncertainty_score":0.002509236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1376843411741889,"score_gpt":0.3133840648821092,"score_spread":0.1756997237079203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}