{"id":"W1989833043","doi":"10.1111/jth.12837","title":"Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses","year":2014,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"iC3b; Plasmin; Chemistry; Complement factor I; Cell biology; Opsonin; Complement receptor; Complement system; Phagocytosis; Immune system; Biochemistry; Biology; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004073688,0.0004228812,0.0003784441,0.0003308721,0.0003631836,0.0009456474,0.0003050579,0.0006765401,0.002489628],"category_scores_gemma":[0.0005093946,0.0001882567,0.0003517584,0.0001781267,0.0003618275,0.0004283354,0.0004370291,0.0008549413,0.0004731265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009269838,"about_ca_system_score_gemma":0.0007052961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085893,"about_ca_topic_score_gemma":0.001439809,"domain_scores_codex":[0.9995238,0.0001143204,0.0000251841,0.00006065829,0.00006632709,0.0002098011],"domain_scores_gemma":[0.9997898,0.00002834747,0.00005201482,0.00002313932,0.00003317381,0.00007363097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002446916,0.0001454163,0.003266674,0.0001657434,0.00005406564,0.0003871409,0.0000750945,0.0003511329,0.976226,0.001070457,0.000953256,0.01485812],"study_design_scores_gemma":[0.0004863867,0.002152413,0.2205781,0.0001610936,0.0003970459,0.002609818,0.0004385363,0.005953151,0.7492369,0.003446591,0.01447648,0.00006345726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797924,0.0110847,0.002250597,0.0009307661,0.0001212025,0.00005475345,0.0002721458,0.00006311057,0.005430328],"genre_scores_gemma":[0.99566,0.00156806,0.0006892161,0.0002192179,0.00006068466,0.00002956682,0.0001331674,0.00001129823,0.001628863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002489628,"threshold_uncertainty_score":0.008328617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04509884904164938,"score_gpt":0.3311826122228235,"score_spread":0.2860837631811741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}