{"id":"W1989841268","doi":"10.1182/blood-2014-04-570879","title":"Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Wellcome Trust; Howard Hughes Medical Institute","keywords":"IRF8; Biology; Immunology; Myeloid; Mutation; Severe combined immunodeficiency; Genetics; Transcription factor; In vivo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135519,0.0003673037,0.0002109788,0.0004927703,0.0002665838,0.000301438,0.0002291372,0.000627336,0.001370536],"category_scores_gemma":[0.0005434031,0.0001086542,0.0001699095,0.0001837364,0.0002962495,0.0001429971,0.0001842406,0.0005067072,0.0004529246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233691,"about_ca_system_score_gemma":0.0001057484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004012987,"about_ca_topic_score_gemma":0.00027929,"domain_scores_codex":[0.9998864,0.00001268631,0.00001331097,0.00003180829,0.00002713503,0.00002861571],"domain_scores_gemma":[0.9997763,0.00007099108,0.00003082123,0.00002259325,0.00001941918,0.00007985579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003338389,0.000207989,0.0657685,0.00008208537,0.00003026894,0.2243874,0.0005740385,0.0004604383,0.6933727,0.0005012677,0.0004924868,0.01378906],"study_design_scores_gemma":[0.00006596072,0.0005465726,0.1038614,0.00002454852,0.00005437975,0.7060308,0.0002861347,0.002781071,0.1786067,0.0005595353,0.007150307,0.00003252798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982964,0.000183565,0.0004168111,0.0001095307,0.00001116444,0.00001008958,0.0001957363,0.00001712351,0.0007595278],"genre_scores_gemma":[0.9987513,0.00008056046,0.0006396897,0.00004379307,0.000009391184,0.00000534637,0.0001715707,0.00000770878,0.0002906835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370536,"threshold_uncertainty_score":0.004584968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006544744895435384,"score_gpt":0.1817416953783759,"score_spread":0.1751969504829405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}