{"id":"W1989841268","doi":"10.1182/blood-2014-04-570879","title":"Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Wellcome Trust; Howard Hughes Medical Institute","keywords":"IRF8; Biology; Immunology; Myeloid; Mutation; Severe combined immunodeficiency; Genetics; Transcription factor; In vivo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936507,0.00009065076,0.00009761065,0.00003683275,0.0003925817,0.00001370087,0.0001244875,0.00008937911,0.0004260966],"category_scores_gemma":[0.00005023921,0.00005111094,0.00006112843,0.0001456873,0.0001206497,0.00008351031,0.00002392851,0.0001897302,0.00008776231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001559369,"about_ca_system_score_gemma":0.00002174367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001674029,"about_ca_topic_score_gemma":0.000008028668,"domain_scores_codex":[0.9992715,0.0002445751,0.000183099,0.0001209621,0.00005265877,0.0001272521],"domain_scores_gemma":[0.9993558,0.00008078143,0.0002307969,0.000199937,0.0001287042,0.000004015963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001831336,0.0002871639,0.00135376,0.000004725295,0.00006226092,7.491496e-8,0.0001958076,0.000007526715,0.9971955,0.0004619973,0.0003191848,0.00009362245],"study_design_scores_gemma":[0.001778928,0.000222074,0.2885313,0.00003188666,0.0001738,0.00002812009,0.0001690402,0.00001342396,0.7055147,0.00002333122,0.003416233,0.00009714859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954868,0.00006676274,0.0006141824,0.0001764143,0.0009049557,0.0001473611,0.000003758591,0.00003082168,0.002568928],"genre_scores_gemma":[0.9903737,0.000002446095,0.000001110428,0.000157578,0.00002047948,0.00001543431,0.0002765829,0.000009747027,0.009142907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2916808,"threshold_uncertainty_score":0.4665459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006544744895435384,"score_gpt":0.1817416953783759,"score_spread":0.1751969504829405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}