{"id":"W1989866840","doi":"10.2174/1566523214666140612154929","title":"Impact of DNA Vector Topology on Non-Viral Gene Therapeutic Safety and Efficacy","year":2014,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Gene delivery; Genetic enhancement; Vector (molecular biology); Viral vector; Plasmid; Vectors in gene therapy; Transfection; Computational biology; Gene; Biology; Transgene; DNA; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006613671,0.0004344259,0.0008003474,0.0007717023,0.0001557159,0.0008792991,0.0004920843,0.0005704753,0.001791017],"category_scores_gemma":[0.0006257136,0.0002097219,0.0002898669,0.0006686014,0.0004352543,0.000824721,0.0003005367,0.0007650808,0.0009126003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000523247,"about_ca_system_score_gemma":0.0005401102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004517804,"about_ca_topic_score_gemma":0.0004520947,"domain_scores_codex":[0.9996872,0.00006448945,0.00003165335,0.0000667148,0.0001187672,0.00003112442],"domain_scores_gemma":[0.999741,0.0001548156,0.0000391939,0.000008105274,0.00004553718,0.00001136161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001965539,0.0000954128,0.000425931,0.01605481,0.00007001138,0.0004322867,0.0001557058,0.001081873,0.1613237,0.01349009,0.003946031,0.8027275],"study_design_scores_gemma":[0.00005289182,0.001018635,0.002919817,0.002721025,0.0003200346,0.005360584,0.0001652997,0.001164298,0.2029983,0.004386936,0.7788065,0.00008572264],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007750561,0.9808431,0.003149585,0.0002617847,0.0001815626,0.00003196836,0.00006681003,0.00003881368,0.007675822],"genre_scores_gemma":[0.02642188,0.9683594,0.002714783,0.0001705975,0.00007279222,0.00004112839,0.00009143399,0.00001433576,0.002113646],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001791017,"threshold_uncertainty_score":0.005991578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04278012071427435,"score_gpt":0.371397564655355,"score_spread":0.3286174439410806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}