{"id":"W1989866840","doi":"10.2174/1566523214666140612154929","title":"Impact of DNA Vector Topology on Non-Viral Gene Therapeutic Safety and Efficacy","year":2014,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Gene delivery; Genetic enhancement; Vector (molecular biology); Viral vector; Plasmid; Vectors in gene therapy; Transfection; Computational biology; Gene; Biology; Transgene; DNA; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001885513,0.0005808719,0.001287307,0.0001228538,0.00006073064,0.00001843084,0.0004313829,0.00039605,0.00004656069],"category_scores_gemma":[0.000014288,0.0004109688,0.0008095221,0.00008710245,0.0001560071,0.000002605004,0.00009336152,0.0002469601,0.00002732874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003841106,"about_ca_system_score_gemma":0.0001964333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008926152,"about_ca_topic_score_gemma":0.000001052184,"domain_scores_codex":[0.9980513,0.000240212,0.0005698875,0.000640932,0.0001290062,0.0003686488],"domain_scores_gemma":[0.9986444,0.00004767354,0.0003771288,0.0007433904,0.00007551034,0.0001119472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003358292,0.0001962461,0.00002884131,0.0003744303,0.0006411183,8.721562e-7,0.00002555206,0.000003505996,0.01542279,0.000008677493,0.0004080226,0.9825541],"study_design_scores_gemma":[0.0015488,0.005459607,0.0009752789,0.0009152504,0.0002579101,0.00003871524,0.000001820995,0.000006861415,0.01218491,0.00002000786,0.9778217,0.0007691588],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09912206,0.8993969,0.0001926782,0.00001036342,0.0005763281,0.0005298671,0.0001250733,0.000008620266,0.00003813435],"genre_scores_gemma":[0.02180523,0.9766193,0.00001504342,0.00006232887,0.0007268246,0.00003163663,0.0006149905,0.00006410697,0.00006054446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9817849,"threshold_uncertainty_score":0.9998342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04278012071427435,"score_gpt":0.371397564655355,"score_spread":0.3286174439410806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}