{"id":"W1989868904","doi":"10.1139/y08-114","title":"Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT<sub>2A</sub>) and histaminergic (H<sub>1</sub>) responses in bovine airway smooth muscle: role of Rho-kinase","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Caveolae; Receptor; Histamine; Cell biology; Serotonergic; Chemistry; Serotonin; Rho-associated protein kinase; Endocrinology; Histaminergic; Internal medicine; Biology; Signal transduction; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008995084,0.0002499154,0.0002430235,0.0001256216,0.0001842322,0.0002739616,0.0002031422,0.0003071609,0.0006292633],"category_scores_gemma":[0.0001115054,0.0001624302,0.0001878657,0.0001230372,0.0002198603,0.0001854877,0.0002146903,0.0003000094,0.00027328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003581079,"about_ca_system_score_gemma":0.0002311917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001875337,"about_ca_topic_score_gemma":0.003288997,"domain_scores_codex":[0.9999065,0.000009700288,0.000009107008,0.00001530952,0.00001892966,0.00004039667],"domain_scores_gemma":[0.999916,0.00001955086,0.00002537323,0.00001058432,0.000009016655,0.00001939449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008688075,0.00001175266,0.0001274101,0.00002211903,0.000005147575,0.00003791903,0.00001010038,0.00001649415,0.9992107,0.00004615372,0.00001774541,0.0004077022],"study_design_scores_gemma":[0.00001955465,0.0001165969,0.005113435,0.000006029817,0.00002213644,0.000274354,0.00002536008,0.0004541932,0.9921132,0.00002488018,0.001825982,0.000004283826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968093,0.001563136,0.0007924993,0.00008849804,0.00001493081,0.00001346865,0.0001752617,0.00002640586,0.0005164817],"genre_scores_gemma":[0.9961693,0.0010036,0.001183968,0.00007550875,0.000007050903,0.000022585,0.0003554975,0.00001607844,0.001166353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001875337,"threshold_uncertainty_score":0.003728867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005050753199992234,"score_gpt":0.237291220488442,"score_spread":0.2322404672884498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}