{"id":"W1989872428","doi":"10.1074/jbc.m809079200","title":"Antimicrobial Peptide-induced Apoptotic Death of Leishmania Results from Calcium-de pend ent, Caspase-independent Mitochondrial Toxicity","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ohio State University; American Heart Association","keywords":"Apoptosis; Toxicity; Peptide; Mitochondrial toxicity; Antimicrobial; Leishmania; Caspase; Chemistry; Mitochondrion; Calcium; Caspase 3; Programmed cell death; Microbiology; Cancer research; Pharmacology; Biochemistry; Biology; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493872,0.0003574878,0.0002335045,0.0002319092,0.0001174561,0.0002469732,0.0002193567,0.0003567204,0.001656717],"category_scores_gemma":[0.0001703806,0.0001194562,0.0002420814,0.0001941454,0.0001725015,0.0002466958,0.0001852194,0.000415555,0.0004770703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002710117,"about_ca_system_score_gemma":0.0001731504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936966,"about_ca_topic_score_gemma":0.0002504581,"domain_scores_codex":[0.9998259,0.00003152464,0.00001979206,0.00002349837,0.0000525634,0.00004670923],"domain_scores_gemma":[0.99991,0.00001291496,0.00002035196,0.00001280676,0.00002339177,0.00002053129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000208371,0.00003217637,0.000150739,0.00008110241,0.000006426834,0.0001139434,0.000008115931,0.00001790598,0.9974571,0.00009145736,0.00003740149,0.001795247],"study_design_scores_gemma":[0.00006166001,0.0005839381,0.006664383,0.00001165809,0.00001552149,0.00140013,0.00002651461,0.0005345283,0.9877602,0.0001169864,0.002820058,0.000004413133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870618,0.005526345,0.003430399,0.0001269292,0.00003777273,0.00004923947,0.0004189357,0.0001014084,0.00324718],"genre_scores_gemma":[0.9941894,0.001766286,0.001360225,0.00006900576,0.00001031789,0.00002978986,0.0005521773,0.00001141102,0.002011494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656717,"threshold_uncertainty_score":0.005542278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06755446011626302,"score_gpt":0.3268585658133474,"score_spread":0.2593041056970844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}