{"id":"W1989872428","doi":"10.1074/jbc.m809079200","title":"Antimicrobial Peptide-induced Apoptotic Death of Leishmania Results from Calcium-de pend ent, Caspase-independent Mitochondrial Toxicity","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ohio State University; American Heart Association","keywords":"Apoptosis; Toxicity; Peptide; Mitochondrial toxicity; Antimicrobial; Leishmania; Caspase; Chemistry; Mitochondrion; Calcium; Caspase 3; Programmed cell death; Microbiology; Cancer research; Pharmacology; Biochemistry; Biology; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006134561,0.0003038453,0.001013493,0.00005604233,0.00008685724,0.00003282817,0.0004152974,0.0004209449,0.0001917931],"category_scores_gemma":[0.00335074,0.0002108779,0.0004865812,0.0001408656,0.00014639,0.00008410693,0.000124584,0.001047895,0.000008128238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354779,"about_ca_system_score_gemma":0.0003038883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000938579,"about_ca_topic_score_gemma":0.000003152474,"domain_scores_codex":[0.9970372,0.0001263329,0.001213331,0.0003971278,0.0006844128,0.0005416338],"domain_scores_gemma":[0.9975299,0.0004158306,0.0007765551,0.0003615617,0.000477564,0.0004385606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003822994,0.0008006878,0.005807497,0.00003533474,0.0002003408,0.0008679232,0.0001158636,0.000005406679,0.9853085,0.00000416584,0.002548008,0.0004832235],"study_design_scores_gemma":[0.004618749,0.001204038,0.1004548,0.0002580736,0.0001156559,0.0007267336,0.000145394,0.00001434663,0.891901,0.0001510008,0.0002224191,0.0001877305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949447,0.0001967583,0.00008451065,0.001720693,0.0001521861,0.0001947036,0.0001006588,0.00002251057,0.002583273],"genre_scores_gemma":[0.9959602,0.0002289718,0.001784358,0.0002186344,0.00157766,0.000001400229,0.00003099875,0.00001273428,0.0001850469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09464733,"threshold_uncertainty_score":0.859935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06755446011626302,"score_gpt":0.3268585658133474,"score_spread":0.2593041056970844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}