{"id":"W1989876648","doi":"10.1038/sj.emboj.7600489","title":"Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway","year":2004,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Cancer Research UK; University of Dundee","keywords":"Biology; Signal transduction; Kinase; Cell biology; Genetics; Transduction (biophysics); Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003283182,0.0001102141,0.00009801194,0.00001926992,0.0001988574,0.0000246744,0.0002108723,0.0000801256,0.00005379695],"category_scores_gemma":[0.00003084325,0.00006130785,0.0001148494,0.00005757927,0.0000948481,0.000007080731,0.00002439065,0.0002048133,0.000005916325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001492185,"about_ca_system_score_gemma":0.0001058264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001355629,"about_ca_topic_score_gemma":0.000006121469,"domain_scores_codex":[0.9992638,0.00006579101,0.0002156026,0.0001197603,0.000170928,0.0001641266],"domain_scores_gemma":[0.9995342,0.00001612235,0.000140076,0.0001791076,0.00007801448,0.00005243038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002338897,0.0001007276,0.00004265797,0.000006315621,0.00004015569,0.000001320303,0.0001558128,0.0002669498,0.9944744,0.0006284305,0.001749183,0.002300163],"study_design_scores_gemma":[0.0009158754,0.000347605,0.0006207955,0.00002113652,0.00002692612,0.0003498043,0.0001816009,0.00001311256,0.977737,0.001152438,0.01853533,0.00009836283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701815,0.0004042942,0.02662911,0.00218985,0.0002185324,0.0001067703,0.00002353266,0.000004591278,0.0002417896],"genre_scores_gemma":[0.9987681,0.00004737106,0.000248369,0.0002192669,0.0005395713,0.000006001493,0.00003131054,0.00001009585,0.0001299391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02858654,"threshold_uncertainty_score":0.2500062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364173933183804,"score_gpt":0.2211747091764141,"score_spread":0.2075329698445761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}