{"id":"W1989898386","doi":"10.1097/00000421-200308001-00006","title":"Role of Biologic Markers in Patient Selection and Application to Disease Prevention","year":2003,"lang":"en","type":"article","venue":"American Journal of Clinical Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Breast cancer; Tamoxifen; Letrozole; Oncology; Internal medicine; Estrogen receptor; Exemestane; Biomarker; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01588961,0.0009145736,0.002212091,0.002292004,0.0005109315,0.002668624,0.001156389,0.00141767,0.003081528],"category_scores_gemma":[0.03964546,0.0003467255,0.0004874367,0.00216956,0.0007649879,0.001448542,0.001179673,0.001907668,0.001435175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006724345,"about_ca_system_score_gemma":0.001278276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310124,"about_ca_topic_score_gemma":0.0009349301,"domain_scores_codex":[0.9932295,0.00508282,0.0003605806,0.0003878842,0.0007889132,0.0001503278],"domain_scores_gemma":[0.97869,0.0144554,0.002145249,0.0009891475,0.002888183,0.0008322306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001344338,0.0003781556,0.4563303,0.0005088417,0.0002576862,0.0003841839,0.0002618773,0.002385158,0.0007876142,0.003822286,0.008394009,0.5251456],"study_design_scores_gemma":[0.0006037006,0.005096713,0.7615142,0.003075738,0.001664633,0.00462166,0.001465696,0.05358299,0.004022188,0.04234589,0.1216682,0.0003383947],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4041778,0.3341842,0.1159385,0.0580556,0.004912104,0.001429671,0.002468567,0.001406495,0.07742714],"genre_scores_gemma":[0.9026603,0.03495094,0.04993043,0.004500817,0.002721286,0.0005138119,0.0008856203,0.00009798087,0.003738874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01588961,"threshold_uncertainty_score":0.08403325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009047812129546872,"score_gpt":0.3526773065101224,"score_spread":0.3436294943805756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}