{"id":"W1989907357","doi":"10.1021/ol063133j","title":"Multiple On-Resin Olefin Metathesis to Form Ring-Expanded Analogues of the Lantibiotic Peptide, Lacticin 3147 A2","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Advanced Foods and Materials Network","keywords":"Lantibiotics; Olefin metathesis; Chemistry; Peptidomimetic; Combinatorial chemistry; Metabolic stability; Stereochemistry; Metathesis; Ring (chemistry); Peptide; Ring-closing metathesis; Olefin fiber; Organic chemistry; Biochemistry; Catalysis; Nisin; Antimicrobial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002606494,0.0001510138,0.0002079634,0.00005017704,0.00006310399,0.00001426147,0.0002852608,0.00007927726,0.00004403428],"category_scores_gemma":[0.0003535778,0.0001038914,0.0002089839,0.0002254505,0.00005434044,0.000002752077,0.00009921542,0.00008028507,0.00002461635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002988154,"about_ca_system_score_gemma":0.00001542519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001048568,"about_ca_topic_score_gemma":0.0004164362,"domain_scores_codex":[0.9989989,0.00003297121,0.0002417957,0.0002820975,0.0001786413,0.000265586],"domain_scores_gemma":[0.9992731,0.00008497144,0.0001017318,0.0004307983,0.00002914298,0.00008021682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004362,0.00005967025,0.008266505,0.000009583874,0.0001124115,0.000001841347,0.00004777965,0.000009312851,0.9889761,0.000009639739,0.001705115,0.0007583733],"study_design_scores_gemma":[0.0002378136,0.00003975585,0.02100844,0.00002182748,0.0000764369,0.000002266116,0.00005568428,0.000007977299,0.9766381,0.000006052715,0.001767541,0.0001381469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967338,0.00003699199,0.000690356,0.002160406,0.00003903832,0.00009488939,0.000009751998,0.000008764835,0.0002260314],"genre_scores_gemma":[0.996334,0.0000117464,0.0003494578,0.003005452,0.0001165499,0.000001232473,0.00001293173,0.00002252251,0.0001461199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01274194,"threshold_uncertainty_score":0.423657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009018993273588512,"score_gpt":0.2246433245385223,"score_spread":0.2156243312649338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}