{"id":"W1989907357","doi":"10.1021/ol063133j","title":"Multiple On-Resin Olefin Metathesis to Form Ring-Expanded Analogues of the Lantibiotic Peptide, Lacticin 3147 A2","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Advanced Foods and Materials Network","keywords":"Lantibiotics; Olefin metathesis; Chemistry; Peptidomimetic; Combinatorial chemistry; Metabolic stability; Stereochemistry; Metathesis; Ring (chemistry); Peptide; Ring-closing metathesis; Olefin fiber; Organic chemistry; Biochemistry; Catalysis; Nisin; Antimicrobial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000177613,0.0004635931,0.0003071478,0.0001632964,0.0001312241,0.000292111,0.0003448091,0.0002945645,0.00186401],"category_scores_gemma":[0.0001569274,0.0001375211,0.0003050129,0.0001570725,0.0001587835,0.0003273345,0.0002787186,0.0005439187,0.0005083535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002714135,"about_ca_system_score_gemma":0.0002479467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003245615,"about_ca_topic_score_gemma":0.0006130239,"domain_scores_codex":[0.9998423,0.00002351077,0.00001066801,0.00004332804,0.00003556581,0.00004462573],"domain_scores_gemma":[0.9999259,0.00001088193,0.00002480008,0.00001340187,0.000008008049,0.00001704735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001065683,0.00003906121,0.00004444726,0.00003787882,0.000008342198,0.00007123661,0.00002015773,0.0001846854,0.9954999,0.0001520752,0.00003927136,0.00379637],"study_design_scores_gemma":[0.00002287993,0.000329159,0.0002545667,0.000002051907,0.000009323916,0.0001515369,0.000009573963,0.0003297088,0.996222,0.00003359936,0.002630227,0.00000522048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666326,0.00162843,0.02363173,0.0001224926,0.0000829614,0.0001522563,0.0003620216,0.0002304294,0.007157082],"genre_scores_gemma":[0.9764284,0.000788141,0.01700777,0.00005723115,0.00001333744,0.00004464007,0.0003731993,0.00008888259,0.005198237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186401,"threshold_uncertainty_score":0.006235778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009018993273588512,"score_gpt":0.2246433245385223,"score_spread":0.2156243312649338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}