{"id":"W1989920563","doi":"10.1016/s0896-6273(01)00263-x","title":"Direct Neural Fate Specification from Embryonic Stem Cells","year":2001,"lang":"en","type":"article","venue":"Neuron","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":759,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Amgen (Canada); Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Neural stem cell; Embryonic stem cell; Neural cell; Biology; Stem cell; Neural development; Precursor cell; Neuroscience; Cell biology; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003932111,0.000449118,0.0003003677,0.0004745522,0.0002809729,0.0007225058,0.0003564667,0.0003394495,0.002653087],"category_scores_gemma":[0.0003617206,0.0003457827,0.0003586846,0.0002741325,0.0002855225,0.0002992101,0.0006864713,0.0009962469,0.002039737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000374606,"about_ca_system_score_gemma":0.000452149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006980135,"about_ca_topic_score_gemma":0.002290081,"domain_scores_codex":[0.9997733,0.0000323377,0.00002176876,0.00003867105,0.00009508311,0.00003873213],"domain_scores_gemma":[0.9997588,0.0001030595,0.00002609086,0.00003860358,0.0000366742,0.00003677527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006611649,0.00001577735,0.000162098,0.0000815629,0.000008661628,0.00009855595,0.00004257889,0.00008983974,0.9903659,0.002283132,0.0002661899,0.006519713],"study_design_scores_gemma":[0.0000217538,0.00004421789,0.001095345,0.0000133927,0.00001415091,0.0001846912,0.00002643672,0.0002812447,0.9848115,0.0005595359,0.01294409,0.000003612794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8209403,0.01533847,0.09223301,0.001332634,0.0006999812,0.0003056682,0.002915554,0.0005804864,0.06565388],"genre_scores_gemma":[0.9232525,0.009156164,0.02199539,0.0003704153,0.0001268295,0.000140878,0.002955279,0.0002826065,0.04171995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002653087,"threshold_uncertainty_score":0.008875489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400905668904593,"score_gpt":0.2554025714427481,"score_spread":0.2313935147537022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}