{"id":"W1989923722","doi":"10.1074/jbc.m109.006049","title":"Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase OatWY from Neisseria meningitidis","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences; University of British Columbia","funders":"British Columbia Knowledge Development Fund; National Research Council Canada; Canadian Institutes of Health Research; University of British Columbia; Kwanjeong Educational Foundation; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; Canadian Light Source; Howard Hughes Medical Institute","keywords":"Polysialic acid; Active site; Sialic acid; Enzyme; Biochemistry; Acetyltransferase; Virulence; Chemistry; Pathogen; Substrate (aquarium); Mutant; Acetylation; Stereochemistry; Biology; Microbiology; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990153,0.0003157498,0.0002592858,0.0001840634,0.0001259139,0.0003317201,0.000350916,0.0002524088,0.0003765067],"category_scores_gemma":[0.000508471,0.0001639983,0.0004054754,0.0003418615,0.0002277258,0.0003164559,0.0001690619,0.000515138,0.0001868827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005076104,"about_ca_system_score_gemma":0.0002633189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0045173,"about_ca_topic_score_gemma":0.002781701,"domain_scores_codex":[0.9998547,0.00001459687,0.00001473026,0.00002572697,0.00005796025,0.00003220665],"domain_scores_gemma":[0.9997111,0.00006213446,0.00009166289,0.00003279553,0.00005248479,0.00004991335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004525824,0.0002434368,0.005791691,0.0000753807,0.00003656618,0.0001199373,0.0001205472,0.002064065,0.9862358,0.0003541431,0.00008753627,0.004418263],"study_design_scores_gemma":[0.00003971014,0.0006392289,0.03526756,0.00000907028,0.00004528463,0.0005142877,0.0001443478,0.01393721,0.9467337,0.0001553288,0.002480877,0.00003342242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981553,0.0003824608,0.0007851094,0.00003260542,0.000003782127,0.000007463672,0.0002701089,0.00001003431,0.0003531172],"genre_scores_gemma":[0.9950299,0.0003873201,0.00175422,0.00001472138,0.000005493658,0.00001190878,0.002014478,0.00001898884,0.0007630517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0045173,"threshold_uncertainty_score":0.008982003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154894386959377,"score_gpt":0.2578384451763856,"score_spread":0.2423490064804479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}