{"id":"W1989930530","doi":"10.1111/j.1747-0285.2009.00909.x","title":"Heme Oxygenase Inhibition by 2‐Oxy‐substituted 1‐Azolyl‐4‐phenylbutanes: Effect of Variation of the Azole Moiety. X‐Ray Crystal Structure of Human Heme Oxygenase‐1 in Complex with 4‐Phenyl‐1‐(1<i>H</i>‐1,2,4‐triazol‐1‐yl)‐2‐butanone<sup>†</sup>","year":2009,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Azole; Moiety; Imidazole; Pharmacophore; Heme oxygenase; Stereochemistry; Triazole; Heme; Tetrazole; 1,2,4-Triazole; Enzyme; Medicinal chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001573495,0.0004038683,0.000284333,0.00006803587,0.00008350185,0.0002195827,0.0004308726,0.0002849392,0.0007115225],"category_scores_gemma":[0.0001630399,0.0001811219,0.000130826,0.0001091806,0.0001966775,0.0001619394,0.00009963658,0.0004952262,0.000256988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201127,"about_ca_system_score_gemma":0.0001856317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009910912,"about_ca_topic_score_gemma":0.001512489,"domain_scores_codex":[0.999892,0.0000272004,0.000008964385,0.00001894854,0.00002602696,0.00002694693],"domain_scores_gemma":[0.9998993,0.00003932921,0.00002719333,0.000007951339,0.000008760374,0.00001760334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004653423,0.00008187415,0.0001032313,0.00006122886,0.00001356006,0.00005673074,0.00001489258,0.0006274403,0.9973512,0.00007990869,0.00008295136,0.001061659],"study_design_scores_gemma":[0.00005884414,0.0003900182,0.0007881937,0.00000328484,0.00001027857,0.00006551374,0.000007381325,0.001325023,0.9966426,0.00001427102,0.0006894661,0.000005207347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993705,0.003223831,0.0009060629,0.0000896049,0.0000501484,0.00003134779,0.000251636,0.00009897901,0.0016435],"genre_scores_gemma":[0.9961315,0.001435989,0.001164051,0.00003967324,0.00001171162,0.00003016679,0.0002872295,0.00002147403,0.0008781904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009910912,"threshold_uncertainty_score":0.002380311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006608995145661619,"score_gpt":0.2214963597865045,"score_spread":0.2148873646408429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}